D
David Altshuler
Researcher at University of Michigan
Publications - 353
Citations - 226195
David Altshuler is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 162, co-authored 345 publications receiving 201782 citations. Previous affiliations of David Altshuler include Vertex Pharmaceuticals & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Correction: Common Genetic Variants and Modification of Penetrance of -Associated Breast Cancer.
Mia M. Gaudet,Tomas Kirchhoff,Todd Green,Joseph Vijai,Joshua M. Korn,Candace Guiducci,Ayellet V. Segrè,Kate McGee,Lesley McGuffog,Christiana Kartsonaki,Jonathan J. Morrison,Sue Healey,Olga M. Sinilnikova,Dominique Stoppa-Lyonnet,Sylvie Mazoyer,Marion Gauthier-Villars,Hagay Sobol,Michel Longy,Marc Frenay,Frans B. L. Hogervorst,Matti A. Rookus,J. Margriet Collée,Nicoline Hoogerbrugge,Kees E. P. van Roozendaal,Marion Piedmonte,Wendy S. Rubinstein,Stacy Nerenstone,Linda Van Le,Stephanie V. Blank,Trinidad Caldés,Miguel de la Hoya,Heli Nevanlinna,Kristiina Aittomäki,Conxi Lázaro,Ignacio Blanco,Adalgeir Arason,Oskar T. Johannsson,Rosa B. Barkardottir,Peter Devilee,O. I. Olopade,Susan L. Neuhausen,Xianshu Wang,Zachary S. Fredericksen,Paolo Peterlongo,Siranoush Manoukian,Monica Barile,Alessandra Viel,Paolo Radice,Catherine M. Phelan,Steven A. Narod,Gad Rennert,Flavio Lejbkowicz,Anath Flugelman,Irene L. Andrulis,Gord Glendon,Hilmi Ozcelik,Amanda E. Toland,Marco Montagna,Emma D'Andrea,Eitan Friedman,Yael Laitman,Åke Borg,Mary S. Beattie,Susan J. Ramus,Susan M. Domchek,Katherine L. Nathanson,Timothy R. Rebbeck,Amanda B. Spurdle,Xiaoqing Chen,Helene Holland,Esther M. John,John L. Hopper,Saundra S. Buys,Mary B. Daly,Melissa C. Southey,Mary Beth Terry,Nadine Tung,Thomas Hansen,Finn Cilius Nielsen,Mark H. Greene,Phuong L. Mai,Ana Osorio,Mercedes Durán,Raquel Andrés,Javier Benitez,Jeffrey N. Weitzel,Judy Garber,Ute Hamann,Susan Peock,Margaret Cook,Clare Oliver,Debra Frost,Radka Platte,D. Gareth Evans,Fiona Lalloo,Ros Eeles,Louise Izatt,Lisa Walker,Jacqueline Eason,Julian Barwell,Andrew K. Godwin,Rita K. Schmutzler,Barbara Wappenschmidt,Stefanie Engert,Norbert Arnold,Dorothea Gadzicki,Michael Dean,Bert Gold,Robert J. Klein,Fergus J. Couch,Georgia Chenevix-Trench,Douglas F. Easton,Mark J. Daly,Antonis C. Antoniou,David Altshuler,Kenneth Offit +115 more
Patent
Computer method and apparatus for analyzing mutations in DNA
David Altshuler,Eric S. Lander +1 more
TL;DR: In this paper, a computer method and apparatus for detecting mutations in DNA fragments is presented, specifically, percent acetonitrile and threshold temperature for use in the denaturing high performance liquid chromatography method of separating DNA fragments, are determined.
Patent
Association of protein kinase C zeta polymorphisms with diabetes
TL;DR: A central role for the gene encoding protein kinase C zeta in diabetes and perhaps in related disorders is disclosed in this paper, where use of single nucleotide polymorphisms in the PKA gene for diagnosis, prediction of clinical course and treatment response, development of new treatments and development of cell-culture based and animal models for research and treatment are disclosed.
Journal ArticleDOI
Risk and Return for the Clinician-Investigator
TL;DR: In this case study, an early-career clinician-investigator discusses impending and future career issues in an interview with an established translational scientist, who then shares ideas about pursuing clinically informed research questions.
Journal ArticleDOI
Atim-44. a phase i first-in-human trial of two adenoviral vectors expressing hsv1-tk and flt3l for treating newly diagnosed resectable malignant glioma: therapeutic reprogramming of the brain immune system
Pedro R. Lowenstein,Daniel A. Orringer,Oren Sagher,Jason Heth,Shawn L. Hervey-Jumper,Aaron Mammoser,Larry Junck,Denise Leung,Yoshie Umemura,Theodore S. Lawrence,Michelle M. Kim,Daniel R. Wahl,Paul E. McKeever,Sandra Camelo-Piragua,Andrew P. Lieberman,Sriram Venneti,Andrea Comba,David Altshuler,Karin M. Muraszko,Maria G. Castro +19 more
TL;DR: Results show for the first time that reprogramming of the host’s brain immune system to recognize gliomas reveals a new approach for the treatment of highly malignant brain tumors.