D
David B. Miklos
Researcher at Stanford University
Publications - 312
Citations - 16175
David B. Miklos is an academic researcher from Stanford University. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 43, co-authored 246 publications receiving 11375 citations. Previous affiliations of David B. Miklos include Harvard University & Lucile Packard Children's Hospital.
Papers
More filters
Journal ArticleDOI
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
Sattva S. Neelapu,Frederick L. Locke,Nancy L. Bartlett,Lazaros J. Lekakis,David B. Miklos,Caron A. Jacobson,Ira Braunschweig,Olalekan O. Oluwole,Tanya Siddiqi,Yi Lin,John M. Timmerman,Patrick J. Stiff,Jonathan W. Friedberg,Ian W. Flinn,Andre Goy,Brian T. Hill,Mitchell R. Smith,Abhinav Deol,Umar Farooq,Peter A. McSweeney,Javier Munoz,Irit Avivi,Januario E. Castro,Jason R. Westin,Julio C. Chavez,Armin Ghobadi,Krishna V. Komanduri,Ronald Levy,Eric D. Jacobsen,Thomas E. Witzig,Patrick M. Reagan,Adrian Bot,John J. Rossi,Lynn Navale,Yizhou Jiang,Jeff Aycock,Meg Elias,David Z. Chang,Jeff Wiezorek,William Y. Go +39 more
TL;DR: Patients with refractory large B‐cell lymphoma who received CAR T‐cell therapy with axi‐cel had high levels of durable response, with a safety profile that included myelosuppression, the cytokine release syndrome, and neurologic events.
Journal ArticleDOI
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial
Frederick L. Locke,Armin Ghobadi,Caron A. Jacobson,David B. Miklos,Lazaros J. Lekakis,Olalekan O. Oluwole,Yi Lin,Ira Braunschweig,Brian T. Hill,John M. Timmerman,Abhinav Deol,Patrick M. Reagan,Patrick J. Stiff,Ian W. Flinn,Umar Farooq,Andre Goy,Peter A. McSweeney,Javier Munoz,Tanya Siddiqi,Julio C. Chavez,Alex F. Herrera,Nancy L. Bartlett,Jeffrey S. Wiezorek,Lynn Navale,Allen Xue,Yizhou Jiang,Adrian Bot,John M. Rossi,Jenny J. Kim,William Y. Go,Sattva S. Neelapu +30 more
TL;DR: Long-term activity and safety outcomes of the ZUMA-1 study suggest that axicabtagene ciloleucel can induce durable responses and a median overall survival of greater than 2 years, and has a manageable relapsed or refractory disease or relapsed after autologous stem-cell transplantation.
Journal ArticleDOI
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
Daniel A. Winer,Shawn Winer,Shawn Winer,Lei Shen,Persis P. Wadia,Jason Yantha,Geoffrey Paltser,Hubert Tsui,Ping Wu,Matthew G. Davidson,Michael N. Alonso,Hwei X Leong,Alec J. Glassford,Maria Caimol,Justin A. Kenkel,Thomas F. Tedder,Tracey McLaughlin,David B. Miklos,H.-M. Dosch,Edgar G. Engleman +19 more
TL;DR: The results establish the importance of B cells and adaptive immunity in insulin resistance and suggest new diagnostic and therapeutic modalities for managing the disease.
Journal ArticleDOI
KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma
Michael Wang,Javier Munoz,Andre Goy,Frederick L. Locke,Caron A. Jacobson,Brian T. Hill,John M. Timmerman,Houston Holmes,Samantha Jaglowski,Ian W. Flinn,Peter A. McSweeney,David B. Miklos,John M. Pagel,Marie José Kersten,Noel Milpied,Henry C. Fung,Max S. Topp,Roch Houot,Amer Beitinjaneh,Weimin Peng,Lianqing Zheng,John M. Rossi,Rajul K. Jain,Arati V. Rao,Patrick M. Reagan +24 more
TL;DR: KTE-X19 induced durable remissions in a majority of patients with relapsed or refractory mantle-cell lymphoma, and led to serious and life-threatening toxic effects that were consistent with those reported with other CAR T-cell therapies.
Journal ArticleDOI
Induction of gadd45 and jnk/sapk-dependent apoptosis following inducible expression of brca1
D. Paul Harkin,Jonathan F. Bean,David B. Miklos,Young-Han Song,Vivi Truong,Christoph Englert,Fred Christians,Leif W. Ellisen,Shyamala Maheswaran,Jonathan D. Oliner,Daniel A. Haber +10 more
TL;DR: The p53-independent induction of GADD45 by BRCA1 and its activation of JNK/SAPK suggest a pathway for BRC a1-induced apoptosis, a signaling pathway potentially linked to GADD 45 gene family members.