David Baltimore

TL;DR: It is found that unpolarized CD4+CD25− T cells engineered to express the MART-127–35 TCR selectively synthesize Th1 cytokines and exhibit a potent Ag-specific lytic granule exocytosis-mediated cytolytic effector function of comparable efficacy to that of CD8+ CTL, therefore, might be useful in clinical immunotherapy.

TL;DR: The data show that virus-specific RNA levels are reduced in cells nonpermissive at the Fv-1 locus, suggesting that restriction of the F v-1 gene product occurs at the level of transcription of the viral genome or at a pre-integration step, or that the RNA transcripts are rapidly degraded after their synthesis.

TL;DR: There was an apparent movement of P120 from the Detergent-insoluble matrix to the detergent-soluble fraction and a concomitant loss of enzymatic activity.

TL;DR: An important property of HSPCs is uncovered that enables them to convert danger signals into versatile cytokine signals for the regulation of stress-induced hematopoiesis and is uncovered in a novel single-cell proteomic platform and mouse genetic models.

TL;DR: In this paper, methods and compositions for delivering a polynucleotide encoding a gene of interest to a target cell using a virus are provided. But, the methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, which include non-Hodgkin's lymphoma and breast cancer; and hematological disorders, including severe combined immunodeficiency.