D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Journal ArticleDOI
Limiting science: a biologist's perspective.
TL;DR: It is argued that the traditional pact between society and its scientists in which the scientist is given the responsibility for determining the direction of his work is a necessary relationship if basic science is to be an effective endeavor.
Journal ArticleDOI
Discovery of the Reverse Transcriptase
TL;DR: Having now met many others who were imitroduced to experimemital sciemice in high school, I can say that there is no other experience that can better prepare one for a life in science.
Posted ContentDOI
Kinetic Inference Resolves Epigenetic Mechanism of Drug Resistance in Melanoma
Yapeng Su,Xiang Lu,Guideng Li,C. Liu,Yan Kong,Jihoon W. Lee,Rachel Ng,Stephanie Wong,Lidia Robert,Charles Warden,Victoria Liu,Jiahuan Chen,Zhuo Wang,Y. Yapeng,Hanjun Cheng,Alphonsus H. C. Ng,Guangrong Qin,Songming Peng,Min Xue,Dazy Johnson,Yi-Teng Xu,Jessica Wang,Xiwei Wu,Ilya Shmulevich,Qihui Shi,Qihui Shi,Raphael D. Levine,Raphael D. Levine,Antoni Ribas,David Baltimore,Jingchuan Guo,James R. Heath,James R. Heath,Wei Wei,Wei Wei +34 more
TL;DR: This work resolves a mechanism connecting tumor epigenetic plasticity with non-genetic adaptive resistance to therapy, using MAPK inhibition of BRAF-mutant melanomas as a model, and highlights the importance of epigenetic Plasticity in therapeutic resistance.
Nucleic Acids, the Genetic Code, and the Synthesis of Macromolecules
Harvey F. Lodish,Arnold Berk,S Lawrence Zipursky,Paul Matsudaira,David Baltimore,James Darnell +5 more
Posted ContentDOI
Bud13 Promotes a Type I Interferon Response by Countering Intron Retention in Irf7
Luke Frankiw,Devdoot Majumdar,Christian Burns,Logan Vlach,Annie Moradian,Michael J. Sweredoski,David Baltimore +6 more
TL;DR: By acting as an antagonist to IR, Bud13 facilitates the expression of genes at which IR occurs, and a subset of introns that share many characteristics with the one found in Irf7 and are spliced in a Bud13-dependent manner are revealed.