D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho
TL;DR: The 3BP-1 protein may be a mediator of SH3 function in transformation inhibition and may link tyrosine kinases to Ras-related proteins.
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A prudent path forward for genomic engineering and germline gene modification
David Baltimore,Paul Berg,Michael R. Botchan,Dana Carroll,R. Alta Charo,George M. Church,Jacob E. Corn,George Q. Daley,George Q. Daley,Jennifer A. Doudna,Marsha Fenner,Henry T. Greely,Martin Jinek,G. Steven Martin,Edward Penhoet,Jennifer M. Puck,Samuel H. Sternberg,Jonathan S. Weissman,Jonathan S. Weissman,Keith R. Yamamoto,Keith R. Yamamoto +20 more
TL;DR: The meeting identified immediate steps to take toward ensuring that the application of genome engineering technology is performed safely and ethically, and identified those areas where action is essential to prepare for future developments.
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MicroRNAs as regulatory elements in immune system logic
Arnav Mehta,David Baltimore +1 more
TL;DR: The mechanisms by which several miRNAs influence immune development and buffer normal haematopoietic output are discussed, first at the level of haematic stem cells, then in innate and adaptive immune cells, and the pathological consequences of dysregulation of these mi RNAs are discussed.
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Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome
TL;DR: The complete 7410 nucleotide sequence of poliovirus type I genome was obtained from cloned cDNA was synthesized and inserted into the Pst I site of plasmid pBR322, and three clones were derived that together provided DNA copies of the entire poliov virus genome.
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Reduction of caveolin and caveolae in oncogenically transformed cells
TL;DR: Observations suggest that functional alterations in caveolae may play a critical role in oncogenic transformation, perhaps by disrupting contact inhibition in transformed cells.