D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Journal ArticleDOI
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends.
Frederick W. Alt,Alfred L. M. Bothwell,Michael Knapp,Edward J. Siden,Elizabeth L. Mather,Marian Koshland,David Baltimore +6 more
TL;DR: It was shown that the 3′ ends of the two μ mRNAs do not cross-hybridize, and apparently two separate 3′ terminal sequences for μ mRNA are encoded in the genome, one that specifies an amino acid sequence appropriate for membrane-binding and a second that is involved in secretion.
Journal ArticleDOI
Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility
TL;DR: Individual protein-binding sites within the mouse immunoglobulin heavy chain and kappa light chain gene enhancers were altered, making it possible to examine the functional role of the sites during transcription.
Journal ArticleDOI
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
Alex Sigal,Jocelyn T. Kim,Jocelyn T. Kim,Alejandro B. Balazs,Erez Dekel,Avi Mayo,Ron Milo,David Baltimore +7 more
TL;DR: Examination of replication from cell-to-cell spread in the presence of clinical drug concentrations using a stochastic infection model finds that replication is intermittent, without substantial accumulation of mutations.
Journal ArticleDOI
The mechanism of RNA recombination in poliovirus.
Karla Kirkegaard,David Baltimore +1 more
TL;DR: The results strongly support a copy choice mechanism for RNA recombination, in which the viral RNA polymerase switches templates during negative strand synthesis.
Journal ArticleDOI
Mammalian Ryk Is a Wnt Coreceptor Required for Stimulation of Neurite Outgrowth
TL;DR: It is reported that mammalian Ryk, unlike the Drosophila Ryk homolog Derailed, functions as a coreceptor along with Frizzled for Wnt ligands, providing a link between Wnt and Dishevelled.