D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.
Clifford M. Snapper,Piotr Zelazowski,Fernando Rosas,Marilyn Kehry,Ming Tian,David Baltimore,William C. Sha +6 more
TL;DR: These data are the first to demonstrate key, independent roles for p50/NF-kappaB in normal B cell maturation to Ig secretion, germ-line CH gene activation, and Ig class switching, as well as mitogenesis, and provide a powerful and well-defined in vitro model system for studying the role of p50-/- B cells in a wide range of normal cellular functions.
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Retroviral expression in embryonic stem cells and hematopoietic stem cells.
TL;DR: The development of a mouse stem cell virus (MSCV) long terminal repeat-based retroviral vector that is expressed in both embryonic stem (ES) cells and hematopoietic stem (HS) cells is reported, demonstrating that DNA methylation is involved in the maintenance of Retroviral repression.
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MicroRNA-125b Potentiates Macrophage Activation
Aadel A. Chaudhuri,Alex Yick Lun So,Nikita Sinha,William S. Gibson,Konstantin D. Taganov,Ryan M. O'Connell,David Baltimore +6 more
TL;DR: The evidence suggests that miR-125b is at least partly responsible for generating the activated nature of macrophages, at least partially by reducing IRF4 levels, and potentiates the functional role of Macrophages in inducing immune responses.
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The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity.
TL;DR: The myristoylated form of c-Abl protein, as well as the P210bcr/abl protein, have been shown by indirect immunofluorescence to associate with F-actin stress fibers in fibroblasts and is an ideal candidate to mediate signal transduction from the cell surface and cytoskeleton to the nucleus.
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Summary statement of the Asilomar conference on recombinant DNA molecules.
TL;DR: The use of recombinant DNA methodology promises to revolutionize the practice of molecular biology and there is every reason to believe that they will have significant practical utility in the future as discussed by the authors.