D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes
TL;DR: RNA was analyzed in the early phase of a one-step growth cycle of HIV-1 infection in T-lymphoid and monocytic cell lines by using PCR amplification of in vitro-synthesized viral cDNAs and found that expression of at least small amounts of the singly spliced message could occur before the accumulation of Rev.
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Broadly neutralizing antibodies abrogate established hepatitis C virus infection
Ype P. de Jong,Ype P. de Jong,Marcus Dorner,Michiel C. Mommersteeg,Jing W. Xiao,Alejandro B. Balazs,Justin B. Robbins,Benjamin Y. Winer,Sherif Gerges,Kevin Vega,Rachael N. Labitt,Bridget M. Donovan,Erick Giang,Anuradha Krishnan,Luis Chiriboga,Michael Charlton,Dennis R. Burton,Dennis R. Burton,David Baltimore,Mansun Law,Charles M. Rice,Alexander Ploss,Alexander Ploss +22 more
TL;DR: It is demonstrated that three broadly nAbs—AR3A, AR3B, and AR4A—delivered with adeno-associated viral vectors can confer protection against viral challenge in humanized mice and can abrogate an ongoing HCV infection in primary hepatocyte cultures and in a human liver chimeric mouse model.
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In vitro synthesis of DNA complementary to rabbit reticulocyte 10S RNA.
TL;DR: The following two articles describe successful syntheses in vitro of DNA copies of various mammalian globin mRNAs, using reverse transcriptase from avian myoblastosis virus, using poly(dT) sequences at their 3′-ends.
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Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus
TL;DR: The majority of cell lines derived by infection of murine bone marrow cells with Abelson murine leukemia virus synthesize a mu chain but no detectable light chain, suggesting that the mu- only phenotype may be an early normal step in the pathway of B lymphocyte maturation.
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Primer Requirement and Template Specificity of the DNA Polymerase of RNA Tumor Viruses
David Baltimore,Donna F. Smoler +1 more
TL;DR: The DNA polymerase of RNA tumor viruses, therefore, have the same requirements for activity as do other DNA polymerases, except that they prefer polyribon nucleotides over polydeoxyribonucleotides as templates.