D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
Papers
More filters
Journal ArticleDOI
Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids.
Christopher S. Seet,Chongbin He,Michael T. Bethune,Suwen Li,Brent Chick,Eric H. Gschweng,Yuhua Zhu,Kenneth Kim,Donald B. Kohn,David Baltimore,Amélie Montel-Hagen +10 more
TL;DR: A serum-free, artificial thymic organoid (ATO) system that supports efficient and reproducible in vitro differentiation and positive selection of conventional human T cells from all sources of HSPCs is described.
Journal ArticleDOI
The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects
Mathis Grossmann,Donald Metcalf,Julie Merryfull,Amer A. Beg,David Baltimore,Steve Gerondakis +5 more
TL;DR: Data indicate the loss of Rel andrelA does not appear to affect pluripotent stem cells; rather, Rel and RelA serve redundant functions in regulating differentiation and survival of committed progenitors in multiple hemopoietic lineages.
Journal ArticleDOI
E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice.
Mark P. Kamps,David Baltimore +1 more
TL;DR: The results demonstrate a causative role for p85E2A-Pbx1 in human acute leukemia and indicate that the oncogenic potential of PbX1 is not limited to pre-B-cell malignancies.
Journal ArticleDOI
Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A
Aadel A. Chaudhuri,Alex Yick Lun So,Arnav Mehta,Aarathi Minisandram,Nikita Sinha,Vanessa D. Jonsson,Dinesh S. Rao,Ryan M. O'Connell,David Baltimore +8 more
TL;DR: Investigating the mechanism by which miR-125b regulates hematopoiesis, it was found that, among a panel of candidate targets, the mRNA for Lin28A, an induced pluripotent stem cell gene, was most repressed by miR -125b in mouse hematoietic stem and progenitor cells.
Journal ArticleDOI
Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation.
Ron Prywes,J. Gordon Foulkes,J. Gordon Foulkes,Naomi Rosenberg,Naomi Rosenberg,David Baltimore,David Baltimore +6 more
TL;DR: Systematic deletion of v-abl sequences showed that only 45,000 to the 130,000 molecular weight ofv-abl sequence in the A-MuLV protein is needed for fibroblast transformation and, at most, slightly more is neededFor lymphoid cell transformation.