David Baltimore

TL;DR: It is shown that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen to confer robust protection against severe sepsis in mice, demonstrating that DNA damage responses, including the ATM and Fanconi Anemia pathways, are important modulators of immune responses and might be exploited to confer protection to inflammation-driven conditions.

TL;DR: The TCR screening prototype will facilitate immunotherapeutic screening and development of T cell therapies and use droplet microfluidics for functional screening and real-time monitoring of single TCR T cell activation upon recognition of target tumor cells.

TL;DR: The molecular breakpoints in cases of cIG- B-cell precursor ALL with the t(1;19) differ from those in cIg+ cases with this translocation, which should allow more timely and appropriate treatment of these aggressive subtypes of the disease.

TL;DR: With the purified replicase-host factor combination, only poly(A)-containing RNAs were copied, and a preference for poliovirus RNA was shown, suggesting that the factor acts at the initiation step of RNA replication.

TL;DR: The mouse thymus contains two forms of terminal deoxynucleotidyl transferase (TdT) which are distinguishable by the salt concentration necessary to elute them from a phosphocellulose column, by their distrubtion among the thymocyte subpopulations, and by their sensitivity to cortisone treatment.