D
David Baltimore
Researcher at California Institute of Technology
Publications - 882
Citations - 168784
David Baltimore is an academic researcher from California Institute of Technology. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 203, co-authored 876 publications receiving 162955 citations. Previous affiliations of David Baltimore include Thomas Jefferson University & Johns Hopkins University.
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The Yin and Yang of microRNAs: leukemia and immunity
TL;DR: This work describes microRNAs having both Yin and Yang characteristics because they can contribute to normal function but also to autoimmunity, myeloproliferation, and cancer (Yin).
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A Computational-Experimental Approach Identifies Mutations That Enhance Surface Expression of an Oseltamivir-Resistant Influenza Neuraminidase
TL;DR: This work demonstrates a combined computational-experimental approach for identifying mutations that enhance neuraminidase surface expression, and describes several specific mutations with the potential to be of relevance to the spread of oseltamivir resistance in pandemic H1N1.
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Human immunodeficiency virus tat-activated expression of poliovirus protein 2A inhibits mRNA translation
Xiao-Hong Sun,David Baltimore +1 more
TL;DR: Protein 2A can, by itself, carry out the inhibition of cellular protein synthesis characteristic of a poliovirus infection and the HIV tat activation provides a very effective method to control gene expression in mammalian cells.
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Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line.
TL;DR: It is demonstrated that Abl proteins can transform hematopoietic cells in the absence of membrane association and suggest that distinct functions of Abl are required for transformation of fibroblast and hematoblastoid cell types.
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Mechanism of induction of RNA tumor viruses by halogenated pyrimidines.
P. Besmer,David Smotkin,W. Haseltine,H. Fan,A. T. Wilson,M. Paskind,Robert A. Weinberg,David Baltimore +7 more
TL;DR: Results from these studies on JLS V-9 cells strongly imply that the search for specific repressors of the segments of mammalian DNA is likely to be successful and that RNA tumor viruses may offer a system in which such repression systems can be identified and investigated.