D
David Brown
Researcher at University of California, Berkeley
Publications - 11
Citations - 292
David Brown is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Receptor tyrosine kinase & Human artificial chromosome. The author has an hindex of 4, co-authored 10 publications receiving 199 citations. Previous affiliations of David Brown include University of California, San Francisco.
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Journal ArticleDOI
Adverse consequences of glucocorticoid medication: psychological, cognitive, and behavioral effects
Lewis L. Judd,Pamela J. Schettler,E. Sherwood Brown,Owen M. Wolkowitz,Esther M. Sternberg,Bruce G. Bender,Karen Bulloch,John A. Cidlowski,E. Ronald de Kloet,Laurence Fardet,Marian Joëls,Donald Y.M. Leung,Bruce S. McEwen,Benno Roozendaal,Elisabeth F.C. van Rossum,Junyoung Ahn,David Brown,Aaron Plitt,Gagandeep Singh +18 more
TL;DR: The risk of clinically significant and sometimes severe psychological, cognitive, and behavioral disturbances that may be associated with glucocorticoid use are highlighted, as well as ways to prevent and treat these disturbances.
Journal ArticleDOI
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
Madeline M. Keenen,David Brown,Lucy D Brennan,Roman Renger,Harrison Khoo,Christopher R. Carlson,Bo Huang,Stephan W. Grill,Stephan W. Grill,Geeta J. Narlikar,Sy Redding,Sy Redding +11 more
TL;DR: In this article, the phase-separation by HP1 proteins can explain the biological properties of HP1-mediated heterochromatin, and the authors suggest a generalizable model for genome organization in which a pool of weakly bound proteins collectively capitalize on the polymer properties of DNA to produce self-organizing domains.
Journal ArticleDOI
Imipramine therapy and seizures: three children treated for hyperactive behavior disorders.
TL;DR: The authors report three cases of children who developed seizures while receiving imipramine treatment for hyperactive-aggressive behavior disorders; all three children had organic brain disease but no previous history of seizures.
Posted ContentDOI
Versatile labeling and detection of endogenous proteins using tag-assisted split enzyme complementation
Suraj Makhija,David Brown,Struan Bourke,Yina Wang,Shuqin Zhou,Shuqin Zhou,Rachel M. Rudlaff,Rasmi Cheloor-Kovilakam,Bo Huang +8 more
TL;DR: The tag-assisted split enzyme complementation (TASEC) approach, which uses two orthogonal small peptide tags and their cognate binders to conditionally drive complementation of a split enzyme upon labeled protein expression, has been developed and engineered and optimized.