Showing papers by "David Cameron published in 1994"
TL;DR: In this paper, thin films of transparent conducting aluminum-doped ZnO have been deposited using a sol-gel process and the dependence of electrical characteristics upon aluminum concentration in the films and upon post-deposition heat treatment in vacuum was examined.
350 citations
TL;DR: Encouraging is the response rate in combination chemotherapy--even for pretreated patients with metastatic disease, response rates up to 89% have been found; however, this level of benefit brings a new toxicity--palmar--plantar erythrodysaesthesia; and of course myelotoxicity still remains a problem in the combination regimens.
Abstract: Prolonged infusions of 5-fluorouracil (5-FU) have been used since the early 1960s, but recently there has been a major resurgence of interest, partly because of the advent of electronically controlled portable infusion pumps. This paper looks at the published data on continuously infused 5-FU in breast cancer. As a single agent, bolus 5-FU has a response rate of around 25%; this includes many patients in older series who were chemotherapy naive. The overall response rate across all the studies with continuously infused 5-FU is 29%. However, the majority of these patients were heavily pretreated, and response rates of up to 54% have been reported. What is more encouraging is the response rate in combination chemotherapy--even for pretreated patients with metastatic disease, response rates up to 89% have been found. However, this level of benefit brings a new toxicity--palmar--plantar erythrodysaesthesia; and of course myelotoxicity still remains a problem in the combination regimens. Randomised trials to assess the role of infusional 5-FU are now indicated.
93 citations
16 citations
TL;DR: In this paper, a closed-field, unbalanced magnetron system was used for carbon nitride (CN x ) thin film deposition in an argon/nitrogen plasma, where the main deposition parameters were magnetron current, total gas pressure and nitrogen gas partial pressure.
Abstract: Carbon nitride (CN x ) thin film deposition was undertaken in a closed-field, unbalanced magnetron system. Reactive deposition utilised a graphite target in an argon/nitrogen plasma. The main deposition parameters investigated were magnetron current, total gas pressure and nitrogen gas partial pressure. The films deposited were examined using IR spectroscopy, ellipsometry, and X-ray diffraction (XRD). Analysis of the results yielded the following characteristics: refractive index of nitrogen-containing films was reduced below that for pure carbon films but had little dependence on substrate bias and total gas pressure. It was, however, strongly dependent on the magnetron current at which the film was deposited. IR spectroscopy showed the transmittance of the films for given deposition conditions to be a monotonic function of nitrogen content. The deposition conditions themselves also had a significant effect, in particular the magnetron current. In addition, C N bonding was evident from the absorption bands observed. Structural analysis by means of XRD showed that the amorphous nature of the films with some degree of graphitic content depended more on the deposition parameters than on the nitrogen concentration. Increased graphitic-type structure was observed at low magnetron currents, high system pressure and large (negative) substrate bias.
15 citations
TL;DR: In this article, the role of ion bombardment on the properties of BN thin films grown by plasma-assisted chemical vapour deposition (PACVD) from borane-ammonia (BH3-NH3), was studied by optical emission spectrometry at different r.f. powers, applying otherwise the same deposition conditions.
10 citations
TL;DR: Infusional 5FU has adequate activity and minimal toxicity when used in relapsed breast cancer, especially in slow-growing chest wall disease, and shows a different pattern of anti-cancer activity and toxicity, when compared with bolus injection.
7 citations
TL;DR: Treatment polices adopted are wide, from no initial treatment to autologous bone marrow transplant in first remission, and there is continuing interest in both the use of newer agents such as purine analogues, as well as radical chemotherapy or radiotherapy.
1 citations