D
David Carling
Researcher at Imperial College London
Publications - 196
Citations - 48565
David Carling is an academic researcher from Imperial College London. The author has contributed to research in topics: AMPK & Protein kinase A. The author has an hindex of 86, co-authored 186 publications receiving 45066 citations. Previous affiliations of David Carling include University of Minnesota & National Institutes of Health.
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Journal ArticleDOI
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Toshimasa Yamauchi,Junji Kamon,Yasuhiko Minokoshi,Yoichi M. Ito,Hironori Waki,S. Uchida,Shigeo Yamashita,Mitsuhiko Noda,Shunbun Kita,K Ueki,Koji Eto,Y. Akanuma,Philippe Froguel,Fabienne Foufelle,Pascal Ferré,David Carling,Shigeko Kimura,Ryozo Nagai,Barbara B. Kahn,Takashi Kadowaki +19 more
TL;DR: It is shown that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full- lengths Ad in the liver, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK.
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AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
TL;DR: Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes.
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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.
Yasuhiko Minokoshi,Young-Bum Kim,Odile D. Peroni,Lee G.D. Fryer,Corinna Müller,David Carling,Barbara B. Kahn +6 more
TL;DR: It is shown that leptin selectively stimulates phosphorylation and activation of the α2 catalytic subunit of AMPK (α2 AMPK) in skeletal muscle, thus establishing a previously unknown signalling pathway for leptin, and identifying AMPK as a principal mediator of the effects of leptin on fatty-acid metabolism in muscle.
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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
Angela Woods,Stephen R. Johnstone,Kristina Dickerson,Fiona C. Leiper,Lee G.D. Fryer,Dietbert Neumann,Uwe Schlattner,Theo Wallimann,Marian Carlson,David Carling +9 more
TL;DR: The results identify a link between two protein kinases, previously thought to lie in unrelated, distinct pathways, that are associated with human diseases.
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The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
TL;DR: AMP-activated protein kinase and SNF1-related protein kinases in higher plants are likely to be involved in the response of plant cells to environmental and/or nutritional stress.