David Cohen

Bio: David Cohen is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Medicine & Autism. The author has an hindex of 83, co-authored 635 publications receiving 37722 citations. Previous affiliations of David Cohen include University of California, Berkeley & University of Michigan.

Les perturbations de l’empathie sont au cœur des troubles des conduites de l’enfant et de l’adolescent

Abstract: Resume Le debat sur les troubles des conduites chez l’enfant et l’adolescent butte sur un conflit nosographique qui peut etre depasse si on adopte une approche dimensionnelle. Cette approche integrative et transnosographique met en lumiere le role joue par les perturbations qui touchent le developpement et la mise en action des processus empathiques. Cette capacite se decline en trois volets, procedural, semantique et biographique. Les etudes empiriques et la clinique psychanalytique revelent l’association entre conduites antisociales et alteration de l’empathie. Les donnees en neuropsychologie, cognition sociale et neuroimagerie, principalement effectuees chez l’adulte, permettent d’eclairer les correlats neuronaux de l’atteinte des processus empathiques.

Repeating a suicide attempt during adolescence: risk and protective factors 12 months after hospitalization

Abstract: Suicide attempts (SAs) are a public health concern in adolescence. A brief hospitalization is recommended, but access to inpatient wards is often not available. In addition, numerous risk factors for SA recurrence have been identified, but few studies have explored protective factors. Here, we aimed to assess the role of both risk and protective factors on SA relapse in a context of free access to inpatient services. We performed a prospective follow-up study of 320 adolescents who were hospitalized for an SA between January 2011 and December 2014 in France. Assessments at baseline included socio-demographics, clinical characteristics, temperament, reasons for living, spirituality, and coping. Patients were re-evaluated at 6 months and 12 months for depression severity and SA relapse. A total of 135 and 91 patients (78 girls, 12 boys, aged 13–17) were followed up at 6 and 12 months, respectively. At the 12-month follow-up, 28 (30%) subjects had repeated an SA. Adolescents who either had a history of SA or were receiving psychotropic treatment at baseline were at higher risk of recurrence. Several variables had a protective effect: (1) productive coping skills, namely, working hard and achieving, physical recreation, and seeking relaxing diversions; (2) a particular temperament trait, namely, cooperativeness; and (3) having experienced more life events. We also found a significant interaction: the higher the depression score during follow-up, the lower the protective effect of productive coping. Our findings confirm that a history of SA and seeking psychiatric care with medication are risk factors for SA relapse. However, productive coping strategies and cooperativeness are protective factors, and the improvement of such strategies as well as treatment of persisting depression should be a goal of psychotherapy treatment offered to suicidal adolescents.

Mothers With Borderline Personality Disorder: Transition to Parenthood, Parent–Infant Interaction, and Preventive/Therapeutic Approach

Abstract: Borderline personality disorder (BPD) is among the most severe and perplexing mental disorders. Adults with BPD appear particularly exposed to severe difficulties in the transition to parenthood, infant caregiving, and the establishment of healthy early interactions. Studies on the offspring of parents with BPD show a high prevalence of social and emotional symptoms, including BPD features. This article reviews the possible consequences of this mental disorder for women during the transition to parenthood, for the quality of early mother–infant relationships, and for infant development. A presentation of a clinical case illustrates these issues, and some features of the preventive/therapeutic approach of these dyads are discussed.

Les antidépresseurs chez l’enfant et l’adolescent : mise au point des données d’efficacité et de tolérance

Abstract: Resume Au cours des dernieres annees, la necessite de disposer d’essais therapeutiques specifiques a la population pediatrique est apparue comme un enjeu important, du fait des particularites cliniques de cette population et des profils de tolerance et de securite qui montrent des differences significatives par rapport a ceux de l’adulte. Cela s’applique, en particulier, aux antidepresseurs, pour lesquels des effets psychocomportementaux specifiques a l’âge ont ete observes dans une proportion faible mais non negligeable de jeunes patients. Cet article propose une mise au point des donnees actuelles d’efficacite et de tolerance concernant les antidepresseurs chez l’enfant et l’adolescent. Le developpement d’etudes collaboratives multicentriques en psychopharmacologie pediatrique a permis de mieux comprendre la place des antidepresseurs parmi les autres strategies therapeutiques dans un certain nombre de troubles internalises de l’enfant et de l’adolescent. Dans la depression de l’enfant, la fluoxetine a obtenu l’autorisation de mise sur le marche (AMM) dans les troubles depressifs majeurs de l’enfant a partir de huit ans. L’efficacite des inhibiteurs selectifs de la recapture de la serotonine (ISRS) est documentee dans le trouble obsessionnel compulsif (TOC) de l’enfant, avec une AMM pour la sertraline et la fluvoxamine en France dans cette indication. Des arguments existent en faveur de l’efficacite des ISRS et de la venlafaxine dans les troubles anxieux – hors TOC – de l’enfant et de l’adolescent, mais sans AMM actuellement dans ces indications. Les donnees de tolerance et de securite (effets psychocomportementaux, incluant les idees et comportements suicidaires, tolerance a long terme, risque lethal) sont egalement passees en revue. Il s’ensuit des propositions de decision incorporant l’ensemble des modalites therapeutiques disponibles pour les trois indications considerees : depression, TOC et autres troubles anxieux de l’enfant et de l’adolescent.

PET imaging studies of dopamine D2 receptors: comparison of [18F]N-methylspiperone and the benzamide analogues [18F]MABN and [18F]MBP in baboon brain.

Abstract: A series of positron emission tomography (PET) imaging studies was conducted in a baboon with the benzamide derivatives [18F]2,3-dimethoxy N-9-(4-fluorobenzyl)-9-azabicyclo[3.3.1]nonan-3β-yl]benzamide ([18F]MABN) and [18F]2,3-dimethoxy-N-[1-(4-fluorobenzyl)piperidin-4-yl]benzamide ([18F]MBP). Studies were also conducted with the butyrophenone [18F]N-methylspiperone (NMSP) for comparison. Tissue-time activity curves of [18F]MABN are similar to those of [18F]NMSP since both compounds displayed approximately the same uptake in the basal ganglia and displayed irreversible binding kinetics in vivo. However, the rapid rate of clearance from the cerebellum and high basal ganglia: cerebellum ratio of [18F]MABN indicate that this compound has a much lower amount of nonspecific binding than [18F]NMSP. [18F]MBP displayed a higher uptake in the basal ganglia relative to [18F]NMSP and [18F]MABN and exhibited reversible binding kinetics in vivo. This property of [18F]MBP is desirable since the uptake of radioactivity in D2-rich ligands is less likely to be influenced by changes in cerebral blood flow. The current data suggest that both [18F]MABN and [18F]MBP are promising ligands for studying dopamine D2 receptors with PET. © 1995 Wiley-Liss, Inc.

Using Multivariate Statistics

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How people learn: Brain, mind, experience, and school.

Abstract: New developments in the science of learning science of learning overview mind and brain how experts differ from novices how children learn learning and transfer the learning environment curriculum, instruction and commnity effective teaching - examples in history, mathematics and science teacher learning technology to support learning conclusions from new developments in the science of learning.

ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation

Abstract: ACE : angiotensin-converting enzyme ACS : acute coronary syndrome ADP : adenosine diphosphate AF : atrial fibrillation AMI : acute myocardial infarction AV : atrioventricular AIDA-4 : Abciximab Intracoronary vs. intravenously Drug Application APACHE II : Acute Physiology Aand Chronic

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Abstract: WRITING GROUP MEMBERS Emelia J. Benjamin, MD, SCM, FAHA Michael J. Blaha, MD, MPH Stephanie E. Chiuve, ScD Mary Cushman, MD, MSc, FAHA Sandeep R. Das, MD, MPH, FAHA Rajat Deo, MD, MTR Sarah D. de Ferranti, MD, MPH James Floyd, MD, MS Myriam Fornage, PhD, FAHA Cathleen Gillespie, MS Carmen R. Isasi, MD, PhD, FAHA Monik C. Jiménez, ScD, SM Lori Chaffin Jordan, MD, PhD Suzanne E. Judd, PhD Daniel Lackland, DrPH, FAHA Judith H. Lichtman, PhD, MPH, FAHA Lynda Lisabeth, PhD, MPH, FAHA Simin Liu, MD, ScD, FAHA Chris T. Longenecker, MD Rachel H. Mackey, PhD, MPH, FAHA Kunihiro Matsushita, MD, PhD, FAHA Dariush Mozaffarian, MD, DrPH, FAHA Michael E. Mussolino, PhD, FAHA Khurram Nasir, MD, MPH, FAHA Robert W. Neumar, MD, PhD, FAHA Latha Palaniappan, MD, MS, FAHA Dilip K. Pandey, MBBS, MS, PhD, FAHA Ravi R. Thiagarajan, MD, MPH Mathew J. Reeves, PhD Matthew Ritchey, PT, DPT, OCS, MPH Carlos J. Rodriguez, MD, MPH, FAHA Gregory A. Roth, MD, MPH Wayne D. Rosamond, PhD, FAHA Comilla Sasson, MD, PhD, FAHA Amytis Towfighi, MD Connie W. Tsao, MD, MPH Melanie B. Turner, MPH Salim S. Virani, MD, PhD, FAHA Jenifer H. Voeks, PhD Joshua Z. Willey, MD, MS John T. Wilkins, MD Jason HY. Wu, MSc, PhD, FAHA Heather M. Alger, PhD Sally S. Wong, PhD, RD, CDN, FAHA Paul Muntner, PhD, MHSc On behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart Disease and Stroke Statistics—2017 Update

Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association

Abstract: Author(s): Writing Group Members; Mozaffarian, Dariush; Benjamin, Emelia J; Go, Alan S; Arnett, Donna K; Blaha, Michael J; Cushman, Mary; Das, Sandeep R; de Ferranti, Sarah; Despres, Jean-Pierre; Fullerton, Heather J; Howard, Virginia J; Huffman, Mark D; Isasi, Carmen R; Jimenez, Monik C; Judd, Suzanne E; Kissela, Brett M; Lichtman, Judith H; Lisabeth, Lynda D; Liu, Simin; Mackey, Rachel H; Magid, David J; McGuire, Darren K; Mohler, Emile R; Moy, Claudia S; Muntner, Paul; Mussolino, Michael E; Nasir, Khurram; Neumar, Robert W; Nichol, Graham; Palaniappan, Latha; Pandey, Dilip K; Reeves, Mathew J; Rodriguez, Carlos J; Rosamond, Wayne; Sorlie, Paul D; Stein, Joel; Towfighi, Amytis; Turan, Tanya N; Virani, Salim S; Woo, Daniel; Yeh, Robert W; Turner, Melanie B; American Heart Association Statistics Committee; Stroke Statistics Subcommittee