David Cohen

Bio: David Cohen is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Medicine & Autism. The author has an hindex of 83, co-authored 635 publications receiving 37722 citations. Previous affiliations of David Cohen include University of California, Berkeley & University of Michigan.

Statin therapy in patients with chronic kidney disease undergoing percutaneous coronary intervention (from the Evaluation of Drug Eluting Stents and Ischemic Events Registry).

Abstract: Secondary prevention trials have demonstrated the efficacy of statins in reducing cardiovascular morbidity and mortality in patients with coronary artery disease and events after percutaneous coronary intervention (PCI). However, there are few data describing the clinical value of statins in patients with coronary artery disease and chronic kidney disease (CKD) undergoing PCI. Of 10,148 patients who entered into Evaluation of Drug Eluting Stents and Ischemic Events, a multicenter registry of unselected patients undergoing PCI from July 2004 to December 2007, we studied 2,306 patients with CKD (estimated glomerular filtration rate ≤60 ml/min based on the Modified Diet in Renal Disease calculation). Patients were stratified into those receiving statins at discharge (n = 1,833, 79%) or not (n = 473, 21%). Patients in the statin group had a greater prevalence of hypertension, recent myocardial infarction (MI), and use of β blockers and angiotensin-converting enzyme inhibitors. Outcomes were assessed from discharge through 1-year follow-up. One-year all-cause mortality was 5.7% in statin group versus 8.7% in the no statin group (adjusted hazard ratio 0.55, 95% confidence interval 0.34 to 0.88). The composite of death, MI, and repeat revascularization was lower in statin group (adjusted hazard ratio 0.71, 95% confidence interval 0.51 to 0.99). In conclusion, among patients with CKD undergoing PCI, the prescription of statins at hospital discharge was associated with a significant improvement in subsequent outcomes including mortality and composite end point of death, MI, and repeat revascularization.

Effectiveness of Wet Sheet Packs in Children and Adolescents with Severe Auto/Hetero Aggressive Behaviors: An Exploratory Approach

Abstract: Objective: To explore the effectiveness of wet sheet packs on auto/hetero aggressive behaviors in children and adolescents hospitalized in a psychiatric setting. Method: We reviewed the charts of all patients (N=8) who received packing therapy in the context of resistance to behavioral interventions, milieu therapy and medications from 2005-2009. We scored the level of auto/hetero aggressive behaviors per patient for each day they were hospitalized. Inter rater reliability was good (Intraclass correlations=0.91). We used a mixed generalized linear model to assess whether the following explanatory variables (time, typical and atypical antipsychotics, mood stabilizer, sedative drug, stimulant and wet sheet pack) influenced the course of aggression over time, the dependant variable. Results: Using univariate analysis, the only variables that were found to be associated with a significant decrease in auto/hetero aggressive score were time (p=8 10 -3 ), atypical antipsychotics (p=.027) and packing therapy (p=10 -9 ). Effect of packing therapy remained significant after adjustment for atypical antipsychotics (p=1.8 10 -9 ) and for time (p=.0017). Conclusion: In addition to atypical antipsychotics and milieu therapy, the results of this exploratory study suggest that wet sheet packs may be effective in relieving auto/hetero aggressive behaviors.

Interpersonal Synchrony: From Social Perception to Social Interaction

Abstract: Introduction Synchrony refers to individuals’ temporal coordination during social interactions (Cappella, 2005). The analysis of this phenomenon is complex, requiring the perception and integration of multimodal communicative signals. The evaluation of synchrony has received multidisciplinary attention because of its role in early development (Feldman, 2003), language learning (Goldstein, King, & West, 2003), and social connection (Harrist & Waugh, 2002). Initially, instances of synchrony were directly perceived in the data by trained observers. Several methods have been proposed to evaluate interactional synchrony, ranging from behavior microanalysis (Cappella, 1997) to global perception of synchrony (Bernieri, Reznick, & Rosenthal, 1988). Behavioral synchrony has now captured the interest of researchers in such fields as social signal processing, robotics, and machine learning (Prepin & Pelachaud, 2011; Kozima, Michalowski, & Nakagawa, 2009). In this chapter, we focus especially on description and definition of synchrony for the development of computational models. The chapter begins with a review of evidences of interpersonal synchrony from different research domains (psychology, clinics, neuroscience and biology). Then, we introduce a working definition of interpersonal synchrony (see Proposed Definition). The chapter surveys evaluation models and methods from the literature of psychology (see Non-computational Methods of Synchrony Assessment) and social signal processing (see Fully Automatic Measures of Synchrony). Finally, the chapter discusses a number of challenges that need to be addressed (see Conclusions and Main Challenges). Non-verbal Evidence of Interpersonal Synchrony Among social signals, synchrony and coordination have been considered lately (Ramseyer & Tschacher, 2010; Delaherche et al., 2012). Condon and Ogston (1967) initially proposed a microanalysis of human behavior (body motion and speech intonation) and evidenced the existence of interactional synchrony, the coordination between listener's and speaker's body movements, or between the listener's body movement and the speaker's pitch and stress variations. Bernieri et al. (1988) define coordination as the “degree to which the behaviors in an interaction are non-random, patterned or synchronized in both form and timing”. (Kendon, 1970) raises fundamental questions about the condition of interactional synchrony arousal and its function in interaction. When he synchronizes with the speaker, the listener demonstrates his ability to anticipate what the speaker is going to say. In this way, he gives feedback to the speaker and smoothens the running of the encounter.

Using Multivariate Statistics

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How people learn: Brain, mind, experience, and school.

Abstract: New developments in the science of learning science of learning overview mind and brain how experts differ from novices how children learn learning and transfer the learning environment curriculum, instruction and commnity effective teaching - examples in history, mathematics and science teacher learning technology to support learning conclusions from new developments in the science of learning.

ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation

Abstract: ACE : angiotensin-converting enzyme ACS : acute coronary syndrome ADP : adenosine diphosphate AF : atrial fibrillation AMI : acute myocardial infarction AV : atrioventricular AIDA-4 : Abciximab Intracoronary vs. intravenously Drug Application APACHE II : Acute Physiology Aand Chronic

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Abstract: WRITING GROUP MEMBERS Emelia J. Benjamin, MD, SCM, FAHA Michael J. Blaha, MD, MPH Stephanie E. Chiuve, ScD Mary Cushman, MD, MSc, FAHA Sandeep R. Das, MD, MPH, FAHA Rajat Deo, MD, MTR Sarah D. de Ferranti, MD, MPH James Floyd, MD, MS Myriam Fornage, PhD, FAHA Cathleen Gillespie, MS Carmen R. Isasi, MD, PhD, FAHA Monik C. Jiménez, ScD, SM Lori Chaffin Jordan, MD, PhD Suzanne E. Judd, PhD Daniel Lackland, DrPH, FAHA Judith H. Lichtman, PhD, MPH, FAHA Lynda Lisabeth, PhD, MPH, FAHA Simin Liu, MD, ScD, FAHA Chris T. Longenecker, MD Rachel H. Mackey, PhD, MPH, FAHA Kunihiro Matsushita, MD, PhD, FAHA Dariush Mozaffarian, MD, DrPH, FAHA Michael E. Mussolino, PhD, FAHA Khurram Nasir, MD, MPH, FAHA Robert W. Neumar, MD, PhD, FAHA Latha Palaniappan, MD, MS, FAHA Dilip K. Pandey, MBBS, MS, PhD, FAHA Ravi R. Thiagarajan, MD, MPH Mathew J. Reeves, PhD Matthew Ritchey, PT, DPT, OCS, MPH Carlos J. Rodriguez, MD, MPH, FAHA Gregory A. Roth, MD, MPH Wayne D. Rosamond, PhD, FAHA Comilla Sasson, MD, PhD, FAHA Amytis Towfighi, MD Connie W. Tsao, MD, MPH Melanie B. Turner, MPH Salim S. Virani, MD, PhD, FAHA Jenifer H. Voeks, PhD Joshua Z. Willey, MD, MS John T. Wilkins, MD Jason HY. Wu, MSc, PhD, FAHA Heather M. Alger, PhD Sally S. Wong, PhD, RD, CDN, FAHA Paul Muntner, PhD, MHSc On behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart Disease and Stroke Statistics—2017 Update

Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association

Abstract: Author(s): Writing Group Members; Mozaffarian, Dariush; Benjamin, Emelia J; Go, Alan S; Arnett, Donna K; Blaha, Michael J; Cushman, Mary; Das, Sandeep R; de Ferranti, Sarah; Despres, Jean-Pierre; Fullerton, Heather J; Howard, Virginia J; Huffman, Mark D; Isasi, Carmen R; Jimenez, Monik C; Judd, Suzanne E; Kissela, Brett M; Lichtman, Judith H; Lisabeth, Lynda D; Liu, Simin; Mackey, Rachel H; Magid, David J; McGuire, Darren K; Mohler, Emile R; Moy, Claudia S; Muntner, Paul; Mussolino, Michael E; Nasir, Khurram; Neumar, Robert W; Nichol, Graham; Palaniappan, Latha; Pandey, Dilip K; Reeves, Mathew J; Rodriguez, Carlos J; Rosamond, Wayne; Sorlie, Paul D; Stein, Joel; Towfighi, Amytis; Turan, Tanya N; Virani, Salim S; Woo, Daniel; Yeh, Robert W; Turner, Melanie B; American Heart Association Statistics Committee; Stroke Statistics Subcommittee