D
David F.M. Brown
Researcher at Harvard University
Publications - 277
Citations - 15376
David F.M. Brown is an academic researcher from Harvard University. The author has contributed to research in topics: Emergency department & Chest pain. The author has an hindex of 48, co-authored 275 publications receiving 14149 citations. Previous affiliations of David F.M. Brown include Beth Israel Deaconess Medical Center & Brigham and Women's Hospital.
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Journal ArticleDOI
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Can Liu,Kevin Kelnar,Bigang Liu,Xin Chen,Tammy Calhoun-Davis,Hangwen Li,Lubna Patrawala,Hong Yan,Collene R. Jeter,Sofia Honorio,Jason F. Wiggins,Andreas G. Bader,Randy Fagin,David F.M. Brown,Dean G. Tang +14 more
TL;DR: This study shows that miR-34a is a key negative regulator of CD44(+) prostate cancer cells and establishes a strong rationale for developing miR -34a as a novel therapeutic agent against prostate CSCs.
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The let-7 MicroRNA represses cell proliferation pathways in human cells
Charles D. Johnson,Aurora Esquela-Kerscher,Giovanni Stefani,Mike Byrom,Kevin Kelnar,Dmitriy Ovcharenko,Michael R. Wilson,Xiaowei Wang,Jeffrey Shelton,Jaclyn Shingara,Lena Chin,David F.M. Brown,Frank J. Slack +12 more
TL;DR: This work reveals the let-7 microRNA to be a master regulator of cell proliferation pathways and shows that multiple genes involved in cell cycle and cell division functions are also directly or indirectly repressed byLet-7.
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The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study.
James L. Januzzi,Carlos A. Camargo,Saif Anwaruddin,Aaron L. Baggish,Annabel A. Chen,Daniel G. Krauser,Roderick Tung,Renee Cameron,J. Tobias Nagurney,Claudia U. Chae,Donald M. Lloyd-Jones,David F.M. Brown,Stacy Foran-Melanson,Patrick M. Sluss,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski +15 more
TL;DR: NT-proBNP measurement is a valuable addition to standard clinical assessment for the identification and exclusion of acute ChF in the emergency department setting and was the strongest independent predictor of a final diagnosis of acute CHF.
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Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
John P. Cogswell,James M. Ward,Ian A. Taylor,Michelle Waters,Yunling Shi,Brian Cannon,Kevin Kelnar,Jon Kemppainen,David F.M. Brown,Caifu Chen,Rab K. Prinjha,Jill C. Richardson,Ann M. Saunders,Allen D. Roses,Cynthia A. Richards +14 more
TL;DR: Using a sensitive qRT-PCR platform, experimental validation is used to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity.
Journal ArticleDOI
Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34
Jason F. Wiggins,Lynnsie Ruffino,Kevin Kelnar,Michael Omotola,Lubna Patrawala,David F.M. Brown,Andreas G. Bader +6 more
TL;DR: The development of a therapeutic formulation using chemically synthesized miR-34a and a lipid-based delivery vehicle that blocks tumor growth in mouse models of non-small-cell lung cancer is described, providing proof of concept for the systemic delivery of a synthetic tumor suppressor mimic.