抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

A comprehensive review of spatiotemporal pattern formation in systems driven away from equilibrium is presented, with emphasis on comparisons between theory and quantitative experiments. Examples include patterns in hydrodynamic systems such as thermal convection in pure fluids and binary mixtures, Taylor-Couette flow, parametric-wave instabilities, as well as patterns in solidification fronts, nonlinear optics, oscillatory chemical reactions and excitable biological media. The theoretical starting point is usually a set of deterministic equations of motion, typically in the form of nonlinear partial differential equations. These are sometimes supplemented by stochastic terms representing thermal or instrumental noise, but for macroscopic systems and carefully designed experiments the stochastic forces are often negligible. An aim of theory is to describe solutions of the deterministic equations that are likely to be reached starting from typical initial conditions and to persist at long times. A unified description is developed, based on the linear instabilities of a homogeneous state, which leads naturally to a classification of patterns in terms of the characteristic wave vector q0 and frequency ω0 of the instability. Type Is systems (ω0=0, q0≠0) are stationary in time and periodic in space; type IIIo systems (ω0≠0, q0=0) are periodic in time and uniform in space; and type Io systems (ω0≠0, q0≠0) are periodic in both space and time. Near a continuous (or supercritical) instability, the dynamics may be accurately described via "amplitude equations," whose form is universal for each type of instability. The specifics of each system enter only through the nonuniversal coefficients. Far from the instability threshold a different universal description known as the "phase equation" may be derived, but it is restricted to slow distortions of an ideal pattern. For many systems appropriate starting equations are either not known or too complicated to analyze conveniently. It is thus useful to introduce phenomenological order-parameter models, which lead to the correct amplitude equations near threshold, and which may be solved analytically or numerically in the nonlinear regime away from the instability. The above theoretical methods are useful in analyzing "real pattern effects" such as the influence of external boundaries, or the formation and dynamics of defects in ideal structures. An important element in nonequilibrium systems is the appearance of deterministic chaos. A greal deal is known about systems with a small number of degrees of freedom displaying "temporal chaos," where the structure of the phase space can be analyzed in detail. For spatially extended systems with many degrees of freedom, on the other hand, one is dealing with spatiotemporal chaos and appropriate methods of analysis need to be developed. In addition to the general features of nonequilibrium pattern formation discussed above, detailed reviews of theoretical and experimental work on many specific systems are presented. These include Rayleigh-Benard convection in a pure fluid, convection in binary-fluid mixtures, electrohydrodynamic convection in nematic liquid crystals, Taylor-Couette flow between rotating cylinders, parametric surface waves, patterns in certain open flow systems, oscillatory chemical reactions, static and dynamic patterns in biological media, crystallization fronts, and patterns in nonlinear optics. A concluding section summarizes what has and has not been accomplished, and attempts to assess the prospects for the future.

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Pattern formation outside of equilibrium

Preface 1. Introduction 2. Conservation laws and differential equations 3. Characteristics and Riemann problems for linear hyperbolic equations 4. Finite-volume methods 5. Introduction to the CLAWPACK software 6. High resolution methods 7. Boundary conditions and ghost cells 8. Convergence, accuracy, and stability 9. Variable-coefficient linear equations 10. Other approaches to high resolution 11. Nonlinear scalar conservation laws 12. Finite-volume methods for nonlinear scalar conservation laws 13. Nonlinear systems of conservation laws 14. Gas dynamics and the Euler equations 15. Finite-volume methods for nonlinear systems 16. Some nonclassical hyperbolic problems 17. Source terms and balance laws 18. Multidimensional hyperbolic problems 19. Multidimensional numerical methods 20. Multidimensional scalar equations 21. Multidimensional systems 22. Elastic waves 23. Finite-volume methods on quadrilateral grids Bibliography Index.

https://depts.washington.edu/clawpack/book2/sample.pdf

Finite Volume Methods for Hyperbolic Problems

Preface Part I. Turbulence: 1. Introduction 2. Coherent structures 3. Proper orthogonal decomposition 4. Galerkin projection Part II. Dynamical Systems: 5. Qualitative theory 6. Symmetry 7. One-dimensional 'turbulence' 8. Randomly perturbed systems Part III. 9. Low-dimensional Models: 10. Behaviour of the models Part IV. Other Applications and Related Work: 11. Some other fluid problems 12. Review: prospects for rigor Bibliography.

/pdf/turbulence-coherent-structures-dynamical-systems-and-fqofnixbu9.pdf

Turbulence, Coherent Structures, Dynamical Systems and Symmetry

Advanced Mathematical Methods for Scientists and Engineers

This book has been written in a frankly partisian spirit-we believe that singularity theory offers an extremely useful approach to bifurcation prob- lems and we hope to convert the reader to this view In this preface we will discuss what we feel are the strengths of the singularity theory approach This discussion then Ieads naturally into a discussion of the contents of the book and the prerequisites for reading it Let us emphasize that our principal contribution in this area has been to apply pre-existing techniques from singularity theory, especially unfolding theory and classification theory, to bifurcation problems Many ofthe ideas in this part of singularity theory were originally proposed by Rene Thom; the subject was then developed rigorously by John Matherand extended by V I Arnold In applying this material to bifurcation problems, we were greatly encouraged by how weil the mathematical ideas of singularity theory meshed with the questions addressed by bifurcation theory Concerning our title, Singularities and Groups in Bifurcation Theory, it should be mentioned that the present text is the first volume in a two-volume sequence In this volume our emphasis is on singularity theory, with group theory playing a subordinate role In Volume II the emphasis will be more balanced Having made these remarks, Iet us set the context for the discussion of the strengths of the singularity theory approach to bifurcation As we use the term, bifurcation theory is the study of equations with multiple solutions

/pdf/singularities-and-groups-in-bifurcation-theory-3jfb7fkeug.pdf

Singularities and groups in bifurcation theory

Instability in the evolution equations describing incompressible granular flow

http://homepage.math.uiowa.edu/~mtchll/2Current.pdf

A two-current model for the dynamics of cardiac membrane.

Singularities and Groups in Bifurcation Theory: Volume I

: This paper applies the theory of singularities of differentiable mappings - specifically the unfolding theorem - to study the effect of imperfections in a system subject to bifurcation. In a number of special cases we have classified (up to a suitable equivalence) all the possible perturbations of the bifurcation equations by a finite number of imperfection parameters. These cases include both bifurcation from a double eigenvalue and from a simple eigenvalue degenerate in the sense of Crandall-Rabinowitz.

David G. Schaeffer

Papers

Singularities and groups in bifurcation theory

Instability in the evolution equations describing incompressible granular flow

A two-current model for the dynamics of cardiac membrane.

Singularities and Groups in Bifurcation Theory: Volume I

A Theory for Imperfect Bifurcation via Singularity Theory.