David Gonzalez

TL;DR: The logic of general synthetic design for lycoricidine, narciclasine, pancratistatin, and 7-deoxypancratianatin is discussed, and truncated derivatives and the compounds from the synthesis of the unnatural derivatives have been tested against six important human cancer cell lines in an effort to further develop the understanding of the mode of action.

TL;DR: In this article, the solution-and solid-phase synthesis of guanidines have been accomplished with a reagent called guanidine reagent, which is used in both solution and solid phase synthesis.

TL;DR: The title alkaloid has been synthesized in eight operations from dibromobenzene and o -vanillin, via enzymatic oxidation of the former compound, Suzuki coupling and a Bischler-Napieralski type cyclization as the key transformations.

TL;DR: Tricyclic compounds that are advanced precursors for the synthesis of analogs of the antitumoral alkaloid pancratistatin were prepared by a short sequence that involved enzymatic dihydroxylation, epoxidation, and intramolecular Huisgen cycloaddition.

TL;DR: The phytochemical analysis of two Chal chal specimens from two well-differentiated geographical zones confirmed that the crystals isolated from sources collected in both countries resulted in the same compound, l-quebrachitol, a natural product not previously reported for this species and one that has been investigated as a sugar substitute for diabetics.