D
David Holcman
Researcher at École Normale Supérieure
Publications - 322
Citations - 8214
David Holcman is an academic researcher from École Normale Supérieure. The author has contributed to research in topics: Brownian motion & Dendritic spine. The author has an hindex of 43, co-authored 292 publications receiving 7057 citations. Previous affiliations of David Holcman include Weizmann Institute of Science & Tel Aviv University.
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Astroglial networks: a step further in neuroglial and gliovascular interactions
TL;DR: Dynamic aspects of interactions between astrocytes, neurons and the vasculature have recently been in the neuroscience spotlight and this intercellular communication between glia has implications for neuroglial and gliovascular interactions.
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The narrow escape problem for diffusion in cellular microdomains
TL;DR: Asymptotic formulas for the mean escape time are presented for a model of a Brownian particle confined to a bounded domain by a reflecting boundary by a small window through which it can escape, and several applications in cellular biology are presented.
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Astroglial networks scale synaptic activity and plasticity.
Ulrike Pannasch,Lydia Vargova,Jürgen Reingruber,Pascal Ezan,David Holcman,Christian Giaume,Eva Syková,Nathalie Rouach +7 more
TL;DR: It is shown that astroglial networks tone down hippocampal synaptic transmission in CA1 pyramidal neurons, establishing connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses.
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Connexin 30 sets synaptic strength by controlling astroglial synapse invasion
Ulrike Pannasch,Dominik Freche,Glenn Dallérac,Grégory Ghézali,Carole Escartin,Pascal Ezan,Martine Cohen-Salmon,Karim Benchenane,Veronica Abudara,Amandine Dufour,Joachim H. R. Lübke,Nicole Déglon,Graham Knott,David Holcman,Nathalie Rouach +14 more
TL;DR: It is shown here in mice that connexin 30 controls hippocampal excitatory synaptic transmission through modulation of astroglial glutamate transport, which directly alters synaptic glutamate levels.
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The emergence of Up and Down states in cortical networks.
TL;DR: It is proposed that the existence of Up–Down states is a fundamental and inherent property of a noisy neural ensemble with sufficiently strong synaptic connections.