D
David J. Finnegan
Researcher at University of Edinburgh
Publications - 49
Citations - 2977
David J. Finnegan is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Transposable element & Insertion sequence. The author has an hindex of 26, co-authored 49 publications receiving 2883 citations.
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Journal ArticleDOI
Eukaryotic transposable elements and genome evolution
TL;DR: The changes in DNA sequence that have taken place during the evolution of eukaryotic genomes cannot be accounted for simply by base substitutions; some more complex mutations must have take place as well.
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The molecular basis of I-R hybrid Dysgenesis in drosophila melanogaster: Identification, cloning, and properties of the I factor
TL;DR: The I factor is not a member of the copia-like or fold-back classes of transposable elements and has no sequence homology with the P factor that controls P-M dysgenesis as discussed by the authors.
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Transposable elements controlling I-R hybrid dysgenesis in D. melanogaster are similar to mammalian LINEs
TL;DR: The base sequences of one complete I factor and the ends of six others are determined, suggesting that I factors transpose by reverse transcription of a full-length RNA.
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Transposition of the Drosophila element mariner into the chicken germ line.
Adrian Sherman,Angela Dawson,Christine Mather,Hazel Gilhooley,Ying Li,Rhona Mitchell,David J. Finnegan,Helen Sang +7 more
TL;DR: Analysis of embryos that survived for at least 12 days of development indicated that mariner had transposed at high frequency into the chicken genome, and mariner has potential for development as a vector for transgenesis in avian species.
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Genome evolution: Sex and the transposable element
TL;DR: Mating systems are thought to play an important role in determining the fate of genomic parasites such as transposable elements and recent studies which indicate that asexual genomes may be structured very differently to those of sexual species.