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David J. Hearse
Researcher at St Thomas' Hospital
Publications - 291
Citations - 13634
David J. Hearse is an academic researcher from St Thomas' Hospital. The author has contributed to research in topics: Ischemia & Ischemic preconditioning. The author has an hindex of 60, co-authored 291 publications receiving 13462 citations. Previous affiliations of David J. Hearse include Brunel University London.
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Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.
TL;DR: It is demonstrated that reperfusion after a period of ischemia results in a sudden increase in the production of free radicals in the myocardium, and ESR signals obtained are consistent with the spin-trapping by PBN of either a carbon-centered species or an alkoxyl radical, both of which could be formed by secondary reactions of initially-formed oxygen radicals with membrane lipid components.
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Reperfusion-induced arrhythmias: Mechanisms and prevention
Allan S. Manning,David J. Hearse +1 more
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Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction
TL;DR: It is concluded that a wide spectrum of collateral flow exists between various mammalian species, a fact that should be taken into account in the study of the pathophysiology and control of regional ischaemia and myocardial infarction.
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The oxygen paradox and the calcium paradox: Two facets of the same problem?
TL;DR: The results suggest that the primary lesion in the calcium paradox is the separation of the basement membrane from the sarcolemma and the energy-dependent loss of intracellular calcium to the extracellular space during the phase of calcium depletion.