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David J. Heeger

Bio: David J. Heeger is an academic researcher from New York University. The author has contributed to research in topics: Visual cortex & Visual system. The author has an hindex of 88, co-authored 268 publications receiving 38154 citations. Previous affiliations of David J. Heeger include Stanford University & Courant Institute of Mathematical Sciences.


Papers
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Journal ArticleDOI
TL;DR: Results from three empirical tests support the hypothesis that fMRI responses in human primary visual cortex (V1) depend separably on stimulus timing and stimulus contrast, and the noise in the fMRI data is independent of stimulus contrast and temporal period.
Abstract: The linear transform model of functional magnetic resonance imaging (fMRI) hypothesizes that fMRI responses are proportional to local average neural activity averaged over a period of time. This work reports results from three empirical tests that support this hypothesis. First, fMRI responses in human primary visual cortex (V1) depend separably on stimulus timing and stimulus contrast. Second, responses to long-duration stimuli can be predicted from responses to shorter duration stimuli. Third, the noise in the fMRI data is independent of stimulus contrast and temporal period. Although these tests can not prove the correctness of the linear transform model, they might have been used to reject the model. Because the linear transform model is consistent with our data, we proceeded to estimate the temporal fMRI impulse-response function and the underlying (presumably neural) contrast-response function of human V1.

2,339 citations

Journal ArticleDOI
TL;DR: A modified version of the linear/energy model is presented in which striate cells mutually inhibit one another, effectively normalizing their responses with respect to stimulus contrast, and shows that the new model explains a significantly larger body of physiological data.
Abstract: Simple cells in the striate cortex have been depicted as half-wave-rectified linear operators. Complex cells have been depicted as energy mechanisms, constructed from the squared sum of the outputs of quadrature pairs of linear operators. However, the linear/energy model falls short of a complete explanation of striate cell responses. In this paper, a modified version of the linear/energy model is presented in which striate cells mutually inhibit one another, effectively normalizing their responses with respect to stimulus contrast. This paper reviews experimental measurements of striate cell responses, and shows that the new model explains a significantly larger body of physiological data.

1,840 citations

Journal ArticleDOI
TL;DR: Normalization was developed to explain responses in the primary visual cortex and is now thought to operate throughout the visual system, and in many other sensory modalities and brain regions, suggesting that it serves as a canonical neural computation.
Abstract: There is increasing evidence that the brain relies on a set of canonical neural computations, repeating them across brain regions and modalities to apply similar operations to different problems. A promising candidate for such a computation is normalization, in which the responses of neurons are divided by a common factor that typically includes the summed activity of a pool of neurons. Normalization was developed to explain responses in the primary visual cortex and is now thought to operate throughout the visual system, and in many other sensory modalities and brain regions. Normalization may underlie operations such as the representation of odours, the modulatory effects of visual attention, the encoding of value and the integration of multisensory information. Its presence in such a diversity of neural systems in multiple species, from invertebrates to mammals, suggests that it serves as a canonical neural computation.

1,619 citations

Journal ArticleDOI
TL;DR: Two examples of jointly shiftable transforms that are simultaneously shiftable in more than one domain are explored and the usefulness of these image representations for scale-space analysis, stereo disparity measurement, and image enhancement is demonstrated.
Abstract: One of the major drawbacks of orthogonal wavelet transforms is their lack of translation invariance: the content of wavelet subbands is unstable under translations of the input signal. Wavelet transforms are also unstable with respect to dilations of the input signal and, in two dimensions, rotations of the input signal. The authors formalize these problems by defining a type of translation invariance called shiftability. In the spatial domain, shiftability corresponds to a lack of aliasing; thus, the conditions under which the property holds are specified by the sampling theorem. Shiftability may also be applied in the context of other domains, particularly orientation and scale. Jointly shiftable transforms that are simultaneously shiftable in more than one domain are explored. Two examples of jointly shiftable transforms are designed and implemented: a 1-D transform that is jointly shiftable in position and scale, and a 2-D transform that is jointly shiftable in position and orientation. The usefulness of these image representations for scale-space analysis, stereo disparity measurement, and image enhancement is demonstrated. >

1,448 citations

Journal ArticleDOI
TL;DR: It is shown that anisotropic diffusion can be seen as a robust estimation procedure that estimates a piecewise smooth image from a noisy input image and the connection to the error norm and influence function in the robust estimation framework leads to a new "edge-stopping" function based on Tukey's biweight robust estimator that preserves sharper boundaries than previous formulations and improves the automatic stopping of the diffusion.
Abstract: Relations between anisotropic diffusion and robust statistics are described in this paper. Specifically, we show that anisotropic diffusion can be seen as a robust estimation procedure that estimates a piecewise smooth image from a noisy input image. The "edge-stopping" function in the anisotropic diffusion equation is closely related to the error norm and influence function in the robust estimation framework. This connection leads to a new "edge-stopping" function based on Tukey's biweight robust estimator that preserves sharper boundaries than previous formulations and improves the automatic stopping of the diffusion. The robust statistical interpretation also provides a means for detecting the boundaries (edges) between the piecewise smooth regions in an image that has been smoothed with anisotropic diffusion. Additionally, we derive a relationship between anisotropic diffusion and regularization with line processes. Adding constraints on the spatial organization of the line processes allows us to develop new anisotropic diffusion equations that result in a qualitative improvement in the continuity of edges.

1,397 citations


Cited by
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Journal ArticleDOI
TL;DR: In this article, a structural similarity index is proposed for image quality assessment based on the degradation of structural information, which can be applied to both subjective ratings and objective methods on a database of images compressed with JPEG and JPEG2000.
Abstract: Objective methods for assessing perceptual image quality traditionally attempted to quantify the visibility of errors (differences) between a distorted image and a reference image using a variety of known properties of the human visual system. Under the assumption that human visual perception is highly adapted for extracting structural information from a scene, we introduce an alternative complementary framework for quality assessment based on the degradation of structural information. As a specific example of this concept, we develop a structural similarity index and demonstrate its promise through a set of intuitive examples, as well as comparison to both subjective ratings and state-of-the-art objective methods on a database of images compressed with JPEG and JPEG2000. A MATLAB implementation of the proposed algorithm is available online at http://www.cns.nyu.edu//spl sim/lcv/ssim/.

40,609 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Book
01 Jan 1998
TL;DR: An introduction to a Transient World and an Approximation Tour of Wavelet Packet and Local Cosine Bases.
Abstract: Introduction to a Transient World. Fourier Kingdom. Discrete Revolution. Time Meets Frequency. Frames. Wavelet Zoom. Wavelet Bases. Wavelet Packet and Local Cosine Bases. An Approximation Tour. Estimations are Approximations. Transform Coding. Appendix A: Mathematical Complements. Appendix B: Software Toolboxes.

17,693 citations

Journal ArticleDOI
TL;DR: It is proved the convergence of a recursive mean shift procedure to the nearest stationary point of the underlying density function and, thus, its utility in detecting the modes of the density.
Abstract: A general non-parametric technique is proposed for the analysis of a complex multimodal feature space and to delineate arbitrarily shaped clusters in it. The basic computational module of the technique is an old pattern recognition procedure: the mean shift. For discrete data, we prove the convergence of a recursive mean shift procedure to the nearest stationary point of the underlying density function and, thus, its utility in detecting the modes of the density. The relation of the mean shift procedure to the Nadaraya-Watson estimator from kernel regression and the robust M-estimators; of location is also established. Algorithms for two low-level vision tasks discontinuity-preserving smoothing and image segmentation - are described as applications. In these algorithms, the only user-set parameter is the resolution of the analysis, and either gray-level or color images are accepted as input. Extensive experimental results illustrate their excellent performance.

11,727 citations

Book ChapterDOI
TL;DR: This chapter demonstrates the functional importance of dopamine to working memory function in several ways and demonstrates that a network of brain regions, including the prefrontal cortex, is critical for the active maintenance of internal representations.
Abstract: Publisher Summary This chapter focuses on the modern notion of short-term memory, called working memory. Working memory refers to the temporary maintenance of information that was just experienced or just retrieved from long-term memory but no longer exists in the external environment. These internal representations are short-lived, but can be maintained for longer periods of time through active rehearsal strategies, and can be subjected to various operations that manipulate the information in such a way that makes it useful for goal-directed behavior. Working memory is a system that is critically important in cognition and seems necessary in the course of performing many other cognitive functions, such as reasoning, language comprehension, planning, and spatial processing. This chapter demonstrates the functional importance of dopamine to working memory function in several ways. Elucidation of the cognitive and neural mechanisms underlying human working memory is an important focus of cognitive neuroscience and neurology for much of the past decade. One conclusion that arises from research is that working memory, a faculty that enables temporary storage and manipulation of information in the service of behavioral goals, can be viewed as neither a unitary, nor a dedicated system. Data from numerous neuropsychological and neurophysiological studies in animals and humans demonstrates that a network of brain regions, including the prefrontal cortex, is critical for the active maintenance of internal representations.

10,081 citations