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David J. Rawlings
Researcher at Seattle Children's Research Institute
Publications - 233
Citations - 19197
David J. Rawlings is an academic researcher from Seattle Children's Research Institute. The author has contributed to research in topics: B cell & Bruton's tyrosine kinase. The author has an hindex of 68, co-authored 211 publications receiving 17092 citations. Previous affiliations of David J. Rawlings include Seattle Children's & Children's Mercy Hospital.
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Journal ArticleDOI
CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
Paul A. Blair,Lina Yassin Noreña,Fabian Flores-Borja,David J. Rawlings,David A. Isenberg,Michael R. Ehrenstein,Claudia Mauri +6 more
TL;DR: It is demonstrated that human CD19(+)CD24(hi)CD38(HI) B cells possessed regulatory capacity, and altered cellular function within this compartment may impact effector immune responses in SLE and other autoimmune disorders.
Journal ArticleDOI
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
Satoshi Tsukada,Douglas C. Saffran,David J. Rawlings,Ornella Parolini,Ornella Parolini,R. Cutler Allen,Ivana Klisak,Robert S. Sparkes,Hiromi Kubagawa,Hiromi Kubagawa,Hiromi Kubagawa,T. K. Mohandas,Shirley G. Quan,John W. Belmont,Max D. Cooper,Max D. Cooper,Max D. Cooper,Mary Ellen Conley,Mary Ellen Conley,Owen N. Witte +19 more
TL;DR: A novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase), which is expressed in all stages of the B lineage and in myeloid cells is described, likely the XLA gene and functions in pathways critical to B cell expansion.
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Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
David J. Rawlings,Douglas C. Saffran,Satoshi Tsukada,David A. Largaespada,J. Christopher Grimaldi,Lucie Cohen,Randolph N. Mohr,J. Fernando Bazan,Maureen C. Howard,Neal G. Copeland,Nancy A. Jenkins,Owen N. Witte +11 more
TL;DR: The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis and a single conserved residue within the amino terminal unique region of Btk was mutated in XID mice, probably interferes with normal B cell signaling mediated by Btk protein interactions.
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Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.
Lauren B. Rodda,Jason Netland,Laila Shehata,Kurt B Pruner,Peter A. Morawski,Christopher D. Thouvenel,Kennidy K Takehara,Julie Eggenberger,Emily A. Hemann,Hayley R Waterman,Mitchell L Fahning,Yu Chen,Yu Chen,Malika Hale,Malika Hale,Jennifer A Rathe,Caleb Stokes,Samuel Wrenn,Brooke Fiala,Lauren Carter,Jessica A. Hamerman,Neil P. King,Michael Gale,Daniel J. Campbell,Daniel J. Campbell,David J. Rawlings,Marion Pepper +26 more
TL;DR: Mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity, and SARS-CoV-2-specific memory lymphocyte exhibited characteristics associated with potent antiviral function.
Journal ArticleDOI
Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis
Jamie G. Evans,Karina A. Chavez-Rueda,Ayad Eddaoudi,Almut Meyer-Bahlburg,David J. Rawlings,Michael R. Ehrenstein,Claudia Mauri +6 more
TL;DR: The ability to regulate an established immune response by T2-MZP B cells endows this subset of B cells with a striking and previously unrecognized immunoregulatory potential.