David J. Richardson

Bio: David J. Richardson is an academic researcher from University of Southampton. The author has contributed to research in topics: Optical fiber & Fiber laser. The author has an hindex of 111, co-authored 1743 publications receiving 53466 citations. Previous affiliations of David J. Richardson include University of Sydney & Karlsruhe Institute of Technology.

Sensing with microstructured optical fibres

Abstract: The optical and geometrical properties of microstructured optical fibres present new alternatives for a range of sensing applications. We present the design criteria for achieving significant overlap between the light guided in the fibre and the air holes and hence for producing efficient evanescent field devices. In addition, the novel dispersive properties combined with the tight mode confinement possible in holey fibres make ultra-broadband single-mode sources and new source wavelengths a possibility. Microstructuring technology can be readily extended to form multiple-core fibres, which have applications in bend/deformation sensing. Finally, fibre-based atom waveguides could ultimately be used for rotational or gravitational sensing.

Self-similarity in ultrafast nonlinear optics

Abstract: Recent developments in nonlinear optics have led to the discovery of a new class of ultrashort pulse, the `optical similariton'. Optical similaritons arise when the interaction of nonlinearity, dispersion and gain in a high-power fibre amplifier causes the shape of an arbitrary input pulse to converge asymptotically to a pulse whose shape is self-similar. In comparison with optical solitons, which rely on a delicate balance of nonlinearity and anomalous dispersion and which can become unstable with increasing intensity, similaritons are more robust at high pulse powers. The simplicity and widespread availability of the components needed to build a self-similar amplifier capable of producing optical similaritons provides a convenient experimental platform to explore the fundamental nature of dynamical self-similarity. Here, we provide an overview of self-similar pulse propagation and scaling in optical fibre amplifiers, and their use in the development of high-power ultrafast optical sources, pulse synthesis and all-optical pulse regeneration.

Interrogation of fiber grating sensor arrays with a wavelength-swept fiber laser

Abstract: We demonstrate a novel application of a wavelength-swept fiber laser to fiber Bragg grating sensor-array interrogation. The laser provides high signal powers of >3 mW with <0.1-nm spectral resolution over a 28-nm wavelength span. Using time-interval counting, we demonstrate static-dynamic strain measurements with a resolution of 0.47mu? rms at a sampling rate of 250 Hz.

Optical fiber nanowires and microwires: fabrication and applications

Abstract: Microwires and nanowires have been manufactured by using a wide range of bottom-up techniques such as chemical or physical vapor deposition and top-down processes such as fiber drawing. Among these techniques, the manufacture of wires from optical fibers provides the longest, most uniform and robust nanowires. Critically, the small surface roughness and the high-homogeneity associated with optical fiber nanowires (OFNs) provide low optical loss and allow the use of nanowires for a wide range of new applications for communications, sensing, lasers, biology, and chemistry. OFNs offer a number of outstanding optical and mechanical properties, including (1) large evanescent fields, (2) high-nonlinearity, (3) strong confinement, and (4) low-loss interconnection to other optical fibers and fiberized components. OFNs are fabricated by adiabatically stretching optical fibers and thus preserve the original optical fiber dimensions at their input and output, allowing ready splicing to standard fibers. A review of the manufacture of OFNs is presented, with a particular emphasis on their applications. Three different groups of applications have been envisaged: (1) devices based on the strong confinement or nonlinearity, (2) applications exploiting the large evanescent field, and (3) devices involving the taper transition regions. The first group includes supercontinuum generators, a range of nonlinear optical devices, and optical trapping. The second group comprises knot, loop, and coil resonators and their applications, sensing and particle propulsion by optical pressure. Finally, mode filtering and mode conversion represent applications based on the taper transition regions. Among these groups of applications, devices exploiting the OFN-based resonators are possibly the most interesting; because of the large evanescent field, when OFNs are coiled onto themselves the mode propagating in the wire interferes with itself to give a resonator. In contrast with the majority of high-Q resonators manufactured by other means, the OFN microresonator does not have major issues with input-output coupling and presents a completely integrated fiberized solution. OFNs can be used to manufacture loop and coil resonators with Q factors that, although still far from the predicted value of 10. The input-output pigtails play a major role in shaping the resonator response and can be used to maximize the Q factor over a wide range of coupling parameters. Finally, temporal stability and robustness issues are discussed, and a solution to optical degradation issues is presented.

Filling the Light Pipe

Abstract: It has been a landmark year for the field of optical telecommunications, with the award of the 2009 Nobel Prize to Charles Kao for his insight in the mid-1960s that the future of communications lay in single-mode silica-based optical fibers (1) as well as the 50th anniversary of the first demonstration of the laser—both key technologies responsible for the development of the global-scale communications networks of today (2). Recently, however, a growing realization has emerged within the telecommunications industry that the end of the phenomenal growth in optical fiber communication capacity is within sight. At this year's Optical Fiber Communication Conference (OFC 2010), several groups reported results within a factor of 2 of the ultimate capacity limits of existing optical fiber technology. Without radical innovation in our physical network infrastructure—that is, improvements in the key physical properties of transmission fibers and the optical amplifiers that we rely on to transmit data over long distances—we face what has been widely referred to as a "capacity crunch" that could severely constrain future Internet growth, as well as having social and political ramifications.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Integrative analysis of 111 reference human epigenomes

Abstract: The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease.

The Observation of Gravitational Waves from a Binary Black Hole Merger

Abstract: On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-Wave Observatory simultaneously observed a transient gravitational-wave signal. The signal sweeps upwards in frequency from 35 to 250 Hz with a peak gravitational-wave strain of 1.0×10(-21). It matches the waveform predicted by general relativity for the inspiral and merger of a pair of black holes and the ringdown of the resulting single black hole. The signal was observed with a matched-filter signal-to-noise ratio of 24 and a false alarm rate estimated to be less than 1 event per 203,000 years, equivalent to a significance greater than 5.1σ. The source lies at a luminosity distance of 410(-180)(+160) Mpc corresponding to a redshift z=0.09(-0.04)(+0.03). In the source frame, the initial black hole masses are 36(-4)(+5)M⊙ and 29(-4)(+4)M⊙, and the final black hole mass is 62(-4)(+4)M⊙, with 3.0(-0.5)(+0.5)M⊙c(2) radiated in gravitational waves. All uncertainties define 90% credible intervals. These observations demonstrate the existence of binary stellar-mass black hole systems. This is the first direct detection of gravitational waves and the first observation of a binary black hole merger.

Climate Change 2007: The Physical Science Basis.

Abstract: Cause, conseguenze e strategie di mitigazione Proponiamo il primo di una serie di articoli in cui affronteremo l’attuale problema dei mutamenti climatici. Presentiamo il documento redatto, votato e pubblicato dall’Ipcc - Comitato intergovernativo sui cambiamenti climatici - che illustra la sintesi delle ricerche svolte su questo tema rilevante.

Photonic crystal fibers

Abstract: Photonic crystal fibers guide light by corralling it within a periodic array of microscopic air holes that run along the entire fiber length Largely through their ability to overcome the limitations of conventional fiber optics—for example, by permitting low-loss guidance of light in a hollow core—these fibers are proving to have a multitude of important technological and scientific applications spanning many disciplines The result has been a renaissance of interest in optical fibers and their uses