D
David L. Mack
Researcher at University of Washington
Publications - 74
Citations - 4706
David L. Mack is an academic researcher from University of Washington. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 26, co-authored 61 publications receiving 4114 citations. Previous affiliations of David L. Mack include Wake Forest Institute for Regenerative Medicine & National Institutes of Health.
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Journal ArticleDOI
New cell lines from mouse epiblast share defining features with human embryonic stem cells
Paul J. Tesar,Josh G. Chenoweth,F. A. Brook,Timothy J. Davies,Edward P. Evans,David L. Mack,Richard L. Gardner,Ronald D.G. McKay +7 more
TL;DR: It is shown that cell lines can be derived from the epiblast, a tissue of the post-implantation embryo that generates the embryo proper, and interrogated to understand how pluripotent cells generate distinct fates during early development.
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Bioprinted Amniotic Fluid-Derived Stem Cells Accelerate Healing of Large Skin Wounds
Aleksander Skardal,David L. Mack,Edi Kapetanovic,Anthony Atala,John D. Jackson,James J. Yoo,Shay Soker +6 more
TL;DR: Bioprinting AFS cells could be an effective treatment for large‐scale wounds and burns, and shows that AFS cell‐conditioned media induced endothelial cell migration in vitro.
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Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo
TL;DR: It is shown that cells from adult seminiferous tubules interact with mammary epithelial cells during regeneration of the gland, providing evidence for the ascendancy of the tissue microenvironment over the intrinsic nature of cells from an alternative adult tissue.
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Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering
Sayed Hadi Mirmalek-Sani,Giuseppe Orlando,John P. McQuilling,Rajesh Pareta,David L. Mack,Marcus Salvatori,Alan C. Farney,Robert J. Stratta,Anthony Atala,Anthony Atala,Emmanuel C. Opara,Shay Soker +11 more
TL;DR: These findings advance the field of regenerative medicine towards the development of a fully functional, bioengineered pancreas capable of establishing and sustaining euglycemia and may be used for transplantation to cure diabetes mellitus.
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Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy
Martin K. Childers,R. Joubert,Karine Poulard,Christelle Moal,Robert W. Grange,Jonathan Doering,Michael W. Lawlor,Michael W. Lawlor,Branden E. Rider,T. Jamet,Nathalie Daniele,Samia Martin,Christel Rivière,Thomas Soker,C. Hammer,Laetitia van Wittenberghe,Mandy Lockard,Xuan Guan,Melissa A. Goddard,Erin Mitchell,Jane Barber,J. Koudy Williams,David L. Mack,Mark E. Furth,Alban Vignaud,Carole Masurier,Fulvio Mavilio,Philippe Moullier,Philippe Moullier,Alan H. Beggs,Anna Buj-Bello +30 more
TL;DR: The results demonstrate the efficacy of gene replacement therapy for myotubular myopathy in animal models and pave the way to a clinical trial in patients, and provide proof of concept for future clinical trials in XLMTM patients.