D
David L. Topping
Researcher at Commonwealth Scientific and Industrial Research Organisation
Publications - 170
Citations - 17510
David L. Topping is an academic researcher from Commonwealth Scientific and Industrial Research Organisation. The author has contributed to research in topics: Resistant starch & Butyrate. The author has an hindex of 56, co-authored 170 publications receiving 15274 citations.
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Journal ArticleDOI
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Yukihiro Furusawa,Yuuki Obata,Shinji Fukuda,Takaho A. Endo,Gaku Nakato,Daisuke Takahashi,Yumiko Nakanishi,Chikako Uetake,Keiko Kato,Tamotsu Kato,Masumi Takahashi,Noriko N. Fukuda,Shinnosuke Murakami,Eiji Miyauchi,Shingo Hino,Koji Atarashi,Satoshi Onawa,Yumiko Fujimura,Trevor Lockett,Julie M. Clarke,David L. Topping,Masaru Tomita,Shohei Hori,Osamu Ohara,Tatsuya Morita,Haruhiko Koseki,Jun Kikuchi,Kenya Honda,Koji Hase,Hiroshi Ohno +29 more
TL;DR: It is shown that a large bowel microbial fermentation product, butyrate, induces the differentiation of colonic Treg cells in mice and ameliorated the development of colitis induced by adoptive transfer of CD4+ CD45RBhi T cells in Rag1−/− mice.
Journal ArticleDOI
Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides
TL;DR: Resistant starch is a prebiotic, but knowledge of its other interactions with the microflora is limited and the contribution of RS to fermentation and colonic physiology seems to be greater than that of NSP.
Journal ArticleDOI
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Shinji Fukuda,Hidehiro Toh,Koji Hase,Kenshiro Oshima,Yumiko Nakanishi,Kazutoshi Yoshimura,Toru Tobe,Julie M. Clarke,David L. Topping,Tohru Suzuki,Todd D. Taylor,Kikuji Itoh,Jun Kikuchi,Jun Kikuchi,Hidetoshi Morita,Masahira Hattori,Hiroshi Ohno,Hiroshi Ohno +17 more
TL;DR: It is proposed that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.
Journal ArticleDOI
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
Eliana Mariño,James L. Richards,Keiran H. McLeod,Dragana Stanley,Yu Anne Yap,Jacinta Knight,Craig R. M. McKenzie,Jan Kranich,Ana Carolina Oliveira,Fernando J. Rossello,Fernando J. Rossello,Fernando J. Rossello,Balasubramanian Krishnamurthy,Christian M. Nefzger,Christian M. Nefzger,Christian M. Nefzger,Laurence Macia,Laurence Macia,Alison N. Thorburn,Alan G. Baxter,Grant Morahan,Lee H. Wong,Jose M. Polo,Jose M. Polo,Jose M. Polo,Robert J. Moore,Trevor Lockett,Julie M. Clarke,David L. Topping,Leonard C. Harrison,Charles R. Mackay +30 more
TL;DR: Medicinal foods or metabolites might represent an effective and natural approach for countering the numerous immunological defects that contribute to T cell–dependent autoimmune diseases.
Journal ArticleDOI
High-amylose wheat generated by RNA interference improves indices of large-bowel health in rats
Ahmed Regina,Anthony R. Bird,David L. Topping,Sarah Bowden,Judy Patricia Freeman,Tina Barsby,Behjat Kosar-Hashemi,Zhongyi Li,Sadequr Rahman,Matthew K. Morell +9 more
TL;DR: When the >70% amylose wheat grain was fed to rats in a diet as a wholemeal, several indices of large-bowel function, including short-chain fatty acids, were improved relative to standard wholemeal wheat.