D
David Lyon
Researcher at University of Copenhagen
Publications - 33
Citations - 15660
David Lyon is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Medicago truncatula & Root nodule. The author has an hindex of 23, co-authored 32 publications receiving 6980 citations. Previous affiliations of David Lyon include Swiss Institute of Bioinformatics & Health Science University.
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STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.
Damian Szklarczyk,Annika L. Gable,David Lyon,Alexander Junge,Stefan Wyder,Jaime Huerta-Cepas,Milan Simonovic,Nadezhda Tsankova Doncheva,John H. Morris,Peer Bork,Lars Juhl Jensen,Christian von Mering +11 more
TL;DR: The latest version of STRING more than doubles the number of organisms it covers, and offers an option to upload entire, genome-wide datasets as input, allowing users to visualize subsets as interaction networks and to perform gene-set enrichment analysis on the entire input.
Journal ArticleDOI
The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets.
Damian Szklarczyk,Annika L. Gable,Katerina C. Nastou,David Lyon,Rebecca Kirsch,Sampo Pyysalo,Nadezhda Tsankova Doncheva,Marc Legeay,Tao Fang,Peer Bork,Lars Juhl Jensen,Christian von Mering +11 more
TL;DR: Changes to the text-mining system, a new scoring-mode for physical interactions, as well as extensive user interface features for customizing, extending and sharing protein networks are described.
Journal ArticleDOI
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation
Ivo A. Hendriks,David Lyon,Clifford Young,Lars Juhl Jensen,Alfred C.O. Vertegaal,Michael L. Nielsen +5 more
TL;DR: An augmented K0–SUMO proteomics strategy is used to identify 40,765 SUMO acceptor sites and quantify their fractional contribution for 6,747 human proteins, providing system-wide evidence for a remarkable degree of cross-talk between SUMOylation and other major PTMs.
Journal ArticleDOI
Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells
Sara Larsen,Kathrine B. Sylvestersen,Andreas Mund,David Lyon,Meeli Mullari,Maria V. Madsen,Jeremy A. Daniel,Lars Juhl Jensen,Michael L. Nielsen +8 more
TL;DR: The presented human arginine methylome provides a missing piece in the global and integrative view of cellular physiology and protein regulation.
Journal ArticleDOI
Site-specific characterization of endogenous SUMOylation across species and organs
Ivo A. Hendriks,David Lyon,Dan Su,Niels H. Skotte,Jeremy A. Daniel,Lars Juhl Jensen,Michael L. Nielsen +6 more
TL;DR: A more sensitive SUMO proteomics approach is developed, providing detailed maps of endogenous SUMO2/3 sites in human cells and mouse tissues, and a resource of endogenoussumOylation sites on factors important in organ-specific functions is provided.