D
David Marsolais
Researcher at Laval University
Publications - 60
Citations - 2100
David Marsolais is an academic researcher from Laval University. The author has contributed to research in topics: Receptor & Dendritic cell. The author has an hindex of 21, co-authored 55 publications receiving 1905 citations. Previous affiliations of David Marsolais include Scripps Research Institute.
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Journal ArticleDOI
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P 1 antagonist in vivo
M. Germana Sanna,Sheng-Kai Wang,Pedro J. Gonzalez-Cabrera,Pedro J. Gonzalez-Cabrera,Anthony S. Don,David Marsolais,Melanie P. Matheu,Sindy H. Wei,Ian Parker,Euijung Jo,Wei-Chieh Cheng,Michael D. Cahalan,Chi-Huey Wong,Hugh Rosen +13 more
TL;DR: Chemical modulation reveals differences in S1P-S1P1 'set points' among tissues and highlights both mechanistic advantages (lymphocyte sequestration) and risks (pulmonary edema) of therapeutic intervention.
Journal ArticleDOI
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules.
David Marsolais,Hugh Rosen +1 more
TL;DR: The role of sphingosine-1-phosphate receptors in the regulation and protection of biological barriers, and the potential of therapeutic strategies that target this receptor family are discussed.
Journal ArticleDOI
Neutrophils and macrophages accumulate sequentially following Achilles tendon injury
TL;DR: Injured tendons exhibited a specific sequence of inflammatory cell accumulation which varied in intensity according to the modality used for collagenase injection, which reduced the extent of inflammation compared with operated animals.
Journal ArticleDOI
Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions
Pedro J. Gonzalez-Cabrera,Euijung Jo,M. Germana Sanna,Steven D. Brown,Nora B. Leaf,David Marsolais,Marie-Therese Schaeffer,Jacqueline Chapman,Michael D. Cameron,Miguel Guerrero,Edward Roberts,Hugh Rosen +11 more
TL;DR: Data show that CYM-5442 activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo through a hydrophobic pocket separate from the orthosteric site of S 1P binding that is headgroup-dependent.
Journal ArticleDOI
A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection.
David Marsolais,Bumsuk Hahm,Kevin B. Walsh,Kurt H. Edelmann,Dorian B. McGavern,Yasuko Hatta,Yoshihiro Kawaoka,Hugh Rosen,Michael B. A. Oldstone +8 more
TL;DR: It is reported that immune modulation by local administration to the respiratory tract of sphingosine analog AAL-R significantly dampens the release of cytokines and chemokines while maintaining protective neutralizing antibody and cytotoxic T cell responses.