D
David McDonald
Researcher at Newcastle University
Publications - 27
Citations - 5150
David McDonald is an academic researcher from Newcastle University. The author has contributed to research in topics: Monocyte & Haematopoiesis. The author has an hindex of 15, co-authored 26 publications receiving 3793 citations. Previous affiliations of David McDonald include Centre for Life.
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Journal ArticleDOI
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.
Alexandra-Chloé Villani,Alexandra-Chloé Villani,Rahul Satija,Rahul Satija,Gary Reynolds,Siranush Sarkizova,Karthik Shekhar,James Fletcher,Morgane Griesbeck,Andrew Butler,Shiwei Zheng,Suzan Lazo,Laura Jardine,David Dixon,Emily Stephenson,Emil Nilsson,Ida Grundberg,David McDonald,Andrew Filby,Weibo Li,Weibo Li,Philip L. De Jager,Philip L. De Jager,Orit Rozenblatt-Rosen,Andrew A. Lane,Andrew A. Lane,Muzlifah Haniffa,Muzlifah Haniffa,Aviv Regev,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +32 more
TL;DR: This refined analysis has identified, among others, a previously unknown dendritic cell population that potently activates T cells and reclassify pDCs as the originally described “natural interferon-producing cells (IPCs)” with weaker T cell proliferation induction ability.
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Alexandra-Chloé Villani,Alexandra-Chloé Villani,Rahul Satija,Rahul Satija,Gary Reynolds,Siranush Sarkizova,Karthik Shekhar,James Fletcher,Morgane Griesbeck,Andrew Butler,Shiwei Zheng,Suzan Lazo,Laura Jardine,David Dixon,Emily Stephenson,Emil Nilsson,Ida Grundberg,David McDonald,Andrew Filby,Weibo Li,Weibo Li,Philip L. De Jager,Philip L. De Jager,Orit Rozenblatt-Rosen,Andrew A. Lane,Andrew A. Lane,Muzlifah Haniffa,Muzlifah Haniffa,Aviv Regev,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +32 more
TL;DR: In this paper, the authors performed single-cell RNA sequencing of ~2400 cells isolated from healthy blood donors and enriched for HLA-DR + lineage − cells, which led them to identify and validate six Dendritic cells (DCs) and four monocyte subtypes.
Journal ArticleDOI
IRF8 mutations and human dendritic-cell immunodeficiency.
Sophie Hambleton,Sandra Salem,Jacinta Bustamante,Venetia Bigley,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Joana Azevedo,Anny Fortin,Muzlifah Haniffa,Muzlifah Haniffa,Lourdes Ceron-Gutierrez,Chris M. Bacon,Chris M. Bacon,Geetha Menon,Céline Trouillet,David McDonald,Peter Carey,Florent Ginhoux,Laia Alsina,Laia Alsina,Timothy J. Zumwalt,Xiao-Fei Kong,Dinakantha S. Kumararatne,Karina Butler,Marjorie Hubeau,Jacqueline Feinberg,Saleh Al-Muhsen,Andrew J. Cant,Laurent Abel,Laurent Abel,Damien Chaussabel,Rainer Doffinger,Eduardo Talesnik,Anete Sevciovic Grumach,Alberto José da Silva Duarte,Katia Abarca,Dewton Moraes-Vasconcelos,David L. Burk,Albert M. Berghuis,Frederic Geissmann,Matthew Collin,Jean-Laurent Casanova,Philippe Gros +42 more
TL;DR: These findings define a class of human primary immunodeficiencies that affect the differentiation of mononuclear phagocytes and show that human IRF8 is critical for the development of monocytes and dendritic cells and for antimycobacterial immunity.
Journal ArticleDOI
Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency
Rachel E. Dickinson,Helen Griffin,Venetia Bigley,Louise N. Reynard,Rafiqul Hussain,Muzlifah Haniffa,Jeremy H. Lakey,Thahira Rahman,Xiao-Nong Wang,Naomi McGovern,Sarah Pagan,Sharon Cookson,David McDonald,Ignatius Chua,Jonathan Wallis,Andrew J. Cant,Michael Wright,Michael Wright,Bernard Keavney,Patrick F. Chinnery,John Loughlin,Sophie Hambleton,Mauro Santibanez-Koref,Matthew Collin +23 more
TL;DR: Because GATA2 is the only common mutated gene in 4 unrelated persons, it is highly probable to be the cause of dendritic cell, monocyte, B, and natural killer lymphoid deficiency and constitutes a new genetic form of heritable immunodeficiency and leukemic transformation.
Journal ArticleDOI
Decoding human fetal liver haematopoiesis
Dorin-Mirel Popescu,Rachel A. Botting,Emily Stephenson,Kile Green,Simone Webb,Laura Jardine,Emily Calderbank,Krzysztof Polanski,Issac Goh,Mirjana Efremova,Meghan Acres,Daniel Maunder,Peter Vegh,Yorick Gitton,Jong-Eun Park,Roser Vento-Tormo,Zhichao Miao,Zhichao Miao,David Dixon,Rachel Rowell,David McDonald,James Fletcher,Elizabeth Poyner,Gary Reynolds,Michael W. Mather,Corina Moldovan,Lira Mamanova,Frankie Greig,Matthew D. Young,Kerstin B. Meyer,Steven Lisgo,Jaume Bacardit,Andrew Fuller,Ben Millar,Barbara A. Innes,Susan Lindsay,Michael J. T. Stubbington,Monika S. Kowalczyk,Bo Li,Orr Ashenberg,Marcin Tabaka,Danielle Dionne,Timothy L. Tickle,Timothy L. Tickle,Michal Slyper,Orit Rozenblatt-Rosen,Andrew Filby,Peter D. Carey,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Anindita Roy,Aviv Regev,Aviv Regev,Alain Chédotal,Irene Roberts,Berthold Göttgens,Sam Behjati,Sam Behjati,Elisa Laurenti,Sarah A. Teichmann,Sarah A. Teichmann,Muzlifah Haniffa,Muzlifah Haniffa +62 more
TL;DR: A shift in the haemopoietic composition of fetal liver during gestation away from being predominantly erythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs is demonstrated, which is validated to produce an integrated map of fetal liver haematopoiesis.