Author
David P. Kelly
Bio: David P. Kelly is an academic researcher from DuPont. The author has contributed to research in topics: Toxicity & Developmental toxicity. The author has an hindex of 11, co-authored 22 publications receiving 473 citations.
Papers
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TL;DR: Exposure to high dust concentrations of two different innocuous particle types produced sustained pulmonary inflammation, enhanced proliferation of pulmonary cells, impairment of particle clearance, deficits in macrophage function, and the appearance of macrophages aggregates at sites of particle deposition.
156 citations
TL;DR: To evaluate the potential subchronic toxicity of DBE, groups of male and female rats were exposed for periods of up to 13 weeks to DBE concentrations of 0, 20, 76, or 390 mg/m3 and were subjected to clinical chemical, hematological, and urine analyses.
52 citations
TL;DR: The lung tumors were a unique type of experimentally induced tumors in the rats and have not been seen as spontaneous tumors in man or animals, therefore, the relevance of this type of lung tumor to the human situation is minimal.
49 citations
TL;DR: The potential chronic toxicity and oncogenicity of hydrochlorofluorocarbon 123 was evaluated by exposing male and female rats to 0, 300, 1000, or 5000 ppm HCFC-123 for 6 hr/day, 5 days/week, for 2 years.
37 citations
TL;DR: Rats exposed to Ludox colloidal silica at concentrations of 0, 10, 50, and 150 mg/m3 for 6 hr/day, 5 days/week for 4 weeks showed changes in pulmonary response and a few aggregates of particleladen AMs appeared to transform into silicotic nodules comprising macrophages, epithelioid cells, and lymphocytic infiltration in some animals.
31 citations
Cited by
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University of Rochester1, Woodrow Wilson International Center for Scholars2, University of Edinburgh3, National Institute for Occupational Safety and Health4, International Life Sciences Institute5, Rice University6, Procter & Gamble7, United States Environmental Protection Agency8, North Carolina State University9, DuPont10
TL;DR: The working group report presents a broad data gathering strategy applicable to this early stage in the development of a risk assessment process for nanomaterials, and there is a strong likelihood that biological activity of nanoparticles will depend on physicochemical parameters not routinely considered in toxicity screening studies.
Abstract: The rapid proliferation of many different engineered nanomaterials (defined as materials designed and produced to have structural features with at least one dimension of 100 nanometers or less) presents a dilemma to regulators regarding hazard identification. The International Life Sciences Institute Research Foundation/Risk Science Institute convened an expert working group to develop a screening strategy for the hazard identification of engineered nanomaterials. The working group report presents the elements of a screening strategy rather than a detailed testing protocol. Based on an evaluation of the limited data currently available, the report presents a broad data gathering strategy applicable to this early stage in the development of a risk assessment process for
2,015 citations
TL;DR: Use of nanosilver is becoming more and more widespread in medicine and related applications and due to increasing exposure toxicological and environmental issues need to be raised.
1,756 citations
27 Oct 1991
TL;DR: In this article, the effects of lead poisoning on the developing developing developing nervous system were investigated, including neurological, neurobehavioral, and developmental effects in children, and toxicity.
Abstract: Essentiality Toxicity Carcinogenicity Lead(Pb) Exposure Toxicokinetics Toxicity Neurologic, Neurobehavioral, and Developmental Effects in Children Mechanisms of Effects on the Developing Nervous System Peripheral Neuropathy Hematologic Effects Renal Toxicity Lead and Gout Effects on Cardiovascular System Immunotoxicity Bone Effects Reproductive Effects Birth Outcomes Carcinogenicity Other Effects Dose Response Treatment Organic Lead Compounds Mercury (Hg) Exposure Disposition and Toxicokinetics Metabolic Transformation Cellular Metabolism Toxicology Biological Indicators Treatment Nickel (Ni) Exposure Toxicokinetics Essentiality Toxicity Nickel Carbonyl Poisoning Dermatitis Indicators of Nickel Toxicity
1,727 citations
TL;DR: itanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications and there is an enormous lack of epidemiological data regarding TiO2 NPs in spite of its increased production and use.
Abstract: Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on the respiratory system, showing the importance of inhalation as the primary route for TiO2 NP exposure in the workplace. TiO2 NPs may translocate to systemic organs from the lung and gastrointestinal tract (GIT) although the rate of translocation appears low. There have also been studies focusing on other potential routes of human exposure. Oral exposure mainly occurs through food products containing TiO2 NP-additives. Most dermal exposure studies, whether in vivo or in vitro, report that TiO2 NPs do not penetrate the stratum corneum (SC). In the field of nanomedicine, intravenous injection can deliver TiO2 nanoparticulate carriers directly into the human body. Upon intravenous exposure, TiO2 NPs can induce pathological lesions of the liver, spleen, kidneys, and brain. We have also shown here that most of these effects may be due to the use of very high doses of TiO2 NPs. There is also an enormous lack of epidemiological data regarding TiO2 NPs in spite of its increased production and use. However, long-term inhalation studies in rats have reported lung tumors. This review summarizes the current knowledge on the toxicology of TiO2 NPs and points out areas where further information is needed.
1,202 citations
TL;DR: Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated thatTiO( 2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract.
1,024 citations