David P. Nicolau

TL;DR: An ODA program at this institution that utilizes a fixed 7-mg/kg intravenous dose with a drug administration interval based on estimated creatinine clearance appears to be clinically effective, reduces the incidence of nephrotoxicity, and provides a cost-effective method for administration of aminoglycosides by reducing ancillary service time and serum am inoglycoside determinations.

TL;DR: Due to 100% fT > MIC achieved in the majority of LRTI patients, fCmin/MIC was the statistically significant parameter associated with meropenem clinical and microbiological response in the adults with LRTi.

TL;DR: There are some patient populations that have not been adequately studied to determine whether or not once-daily aminoglycoside dosing would be a better choice than traditional dosing regimens, and a similar regimen can be applied to amikacin dosing.

TL;DR: Levofloxacin, owing to its larger AUC0–24 values, has excellent and sustained activity against different pneumococcal strains superior to that of ciprofloxacins, and ampicillin showed rapid and sustained bactericidal activity against all isolates.

TL;DR: A more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect.