D
David P. Siderovski
Researcher at West Virginia University
Publications - 183
Citations - 20612
David P. Siderovski is an academic researcher from West Virginia University. The author has contributed to research in topics: Heterotrimeric G protein & G protein. The author has an hindex of 62, co-authored 180 publications receiving 19698 citations. Previous affiliations of David P. Siderovski include Amgen & University of Toronto.
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Journal ArticleDOI
Molecular characterization of mitochondrial apoptosis-inducing factor
Santos A. Susin,Hans K. Lorenzo,Naoufal Zamzami,Isabel Marzo,Bryan E. Snow,Joan Mangion,Etienne Jacotot,Paola Costantini,Markus Loeffler,Nathanael Larochette,David R. Goodlett,Ruedi Aebersold,David P. Siderovski,Josef M. Penninger,Guido Kroemer +14 more
TL;DR: The identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei is reported, indicating that AIF is a mitochondrial effector of apoptotic cell death.
Journal ArticleDOI
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
Vuk Stambolic,Vuk Stambolic,Akira Suzuki,Akira Suzuki,José Luis de la Pompa,José Luis de la Pompa,Christine Mirtsos,Christine Mirtsos,Takehiko Sasaki,Takehiko Sasaki,Jürgen Ruland,Jürgen Ruland,Josef M. Penninger,Josef M. Penninger,David P. Siderovski,David P. Siderovski,Tak W. Mak,Tak W. Mak +17 more
TL;DR: The results show that PTEN may exert its role as a tumor suppressor by negatively regulating the PI3'K/PKB/Akt signaling pathway.
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5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II
Susan McCracken,Nova Fong,Emanuel Rosonina,Krassimir Yankulov,David P. Siderovski,Andrew Hessel,Foster Stephen,Amgen Est Program,Stewart Shuman,David Bentley +9 more
TL;DR: Results suggest that Pol II-specific capping of nascent transcripts in vivo is enhanced by recruitment of the capping enzymes to the CTD and capping is co-ordinated with CTD phosphorylation.
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G-protein signaling: back to the future
Christopher R. McCudden,Melinda D. Hains,Randall J. Kimple,David P. Siderovski,Francis S. Willard +4 more
TL;DR: In this paper, the authors revisited classical heterotrimeric G-protein signaling and explored these new, non-canonical Gprotein signaling pathways, including a receptor-independent Gα nucleotide cycle that regulates cell division.
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The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.
TL;DR: More recent discoveries that have highlighted newly-appreciated roles for RGS proteins beyond mere negative regulators of 7TM signaling are reviewed, including the RGS-box-containing, RhoA-specific guanine nucleotide exchange factors (RGS-RhoGEFs) that serve as Gα effectors to couple 7TM and semaphorin receptor signaling to RHoA activation.