D
David Pellman
Researcher at Howard Hughes Medical Institute
Publications - 142
Citations - 24991
David Pellman is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Mitosis & Spindle apparatus. The author has an hindex of 74, co-authored 135 publications receiving 21838 citations. Previous affiliations of David Pellman include Harvard University & University of Chicago.
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Absolute quantification of somatic DNA alterations in human cancer
Scott L. Carter,Kristian Cibulskis,Elena Helman,Elena Helman,Aaron McKenna,Hui Shen,Travis I. Zack,Peter W. Laird,Robert C. Onofrio,Wendy Winckler,Barbara A. Weir,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,David Pellman,Douglas A. Levine,Eric S. Lander,Eric S. Lander,Eric S. Lander,Matthew Meyerson,Matthew Meyerson,Gad Getz +21 more
TL;DR: A computational method that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations is described, revealing that genome-doubling events are common in human cancer, likely occur in cells that are already aneuploid, and influence pathways of tumor progression.
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A Mechanism Linking Extra Centrosomes to Chromosomal Instability
TL;DR: It is demonstrated that cells with multiple centrosomes rarely undergo multipolar cell divisions, and the progeny of these divisions are typically inviable, and it is proposed that this mechanism may be a common underlying cause of CIN in human cancer.
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DNA breaks and chromosome pulverization from errors in mitosis
Karen Crasta,Neil J. Ganem,Neil J. Ganem,Regina Dagher,Regina Dagher,Alexandra B. Lantermann,Elena Ivanova,Yunfeng Pan,Luigi Nezi,Alexei Protopopov,Dipanjan Chowdhury,David Pellman,David Pellman +12 more
TL;DR: A mechanism by which errors in mitotic chromosome segregation generate DNA breaks via the formation of structures called micronuclei is identified, which potentially lead to mutations and chromosome rearrangements that can integrate into the genome.
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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53 -null cells
Takeshi Fujiwara,Madhavi Bandi,Masayuki Nitta,Elena Ivanova,Roderick T. Bronson,David Pellman +5 more
TL;DR: Tetraploidy enhances the frequency of chromosomal alterations and promotes tumour development in p53-/- MMECs, and MMP overexpression is linked to mammary tumours in humans and animal models.
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Chromothripsis from DNA damage in micronuclei
Cheng-Zhong Zhang,Alexander Spektor,Hauke Cornils,Joshua M. Francis,Emily K. Jackson,Shiwei Liu,Matthew Meyerson,David Pellman +7 more
TL;DR: It is demonstrated that micronucleus formation can indeed generate a spectrum of genomic rearrangements, some of which recapitulate all known features of chromothripsis.