D
David Piwnica-Worms
Researcher at University of Texas MD Anderson Cancer Center
Publications - 291
Citations - 22611
David Piwnica-Worms is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: In vivo & Cancer. The author has an hindex of 70, co-authored 278 publications receiving 20422 citations. Previous affiliations of David Piwnica-Worms include Washington University in St. Louis.
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Journal ArticleDOI
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Sonia A. Melo,Linda B. Luecke,Christoph Kahlert,Agustín F. Fernández,Seth T. Gammon,Judith Kaye,Valerie S. LeBleu,Elizabeth A. Mittendorf,Juergen Weitz,Nuh N. Rahbari,Christoph Reissfelder,Christian Pilarsky,Mario F. Fraga,David Piwnica-Worms,Raghu Kalluri +14 more
TL;DR: GPC1+ crExos may serve as a potential non-invasive diagnostic and screening tool to detect early stages of pancreatic cancer to facilitate possible curative surgical therapy.
Journal ArticleDOI
Whole-genome analysis informs breast cancer response to aromatase inhibition
Matthew J. Ellis,Li Ding,Dong Shen,Jingqin Luo,Vera J. Suman,John W. Wallis,Brian A. Van Tine,Jeremy Hoog,Reece J. Goiffon,Theodore C. Goldstein,Sam Ng,Li Lin,Robert J. Crowder,Jacqueline E. Snider,Karla V. Ballman,Jason D. Weber,Ken Chen,Daniel C. Koboldt,Cyriac Kandoth,William Schierding,Joshua F. McMichael,Christopher A. Miller,Charles Lu,Chris Harris,Michael D. McLellan,Michael C. Wendl,Katherine DeSchryver,D. Craig Allred,Laura J. Esserman,Gary Unzeitig,Julie A. Margenthaler,Gildy Babiera,P. Kelly Marcom,J. M. Guenther,Marilyn Leitch,Kelly K. Hunt,John A. Olson,Yu Tao,Christopher G. Maher,Lucinda Fulton,Robert S. Fulton,Michelle Harrison,Ben Oberkfell,Feiyu Du,Ryan Demeter,Tammi L. Vickery,Adnan Elhammali,Helen Piwnica-Worms,Helen Piwnica-Worms,Sandra McDonald,Mark A. Watson,David J. Dooling,David M. Ota,Li-Wei Chang,Ron Bose,Timothy J. Ley,David Piwnica-Worms,Joshua M. Stuart,Richard K. Wilson,Elaine R. Mardis +59 more
TL;DR: To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant aromatase inhibitor therapy are studied by massively parallel sequencing and analysis.
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Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance
Xuefang Cao,Sheng F. Cai,Todd A. Fehniger,Jiling Song,Lynne Collins,David Piwnica-Worms,Timothy J. Ley +6 more
TL;DR: It is shown here that granzyme B-deficient mice clear both allogeneic and syngeneic tumor cell lines more efficiently than do wild-type (WT) mice and Granzyme B and perforin are relevant for Treg cell-mediated suppression of tumor clearance in vivo.
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Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
Jonathan B. Mitchem,Donal J. Brennan,Brett L. Knolhoff,Brian A. Belt,Yu Zhu,Dominic E. Sanford,Larisa Belaygorod,Danielle Carpenter,Lynne Collins,David Piwnica-Worms,Stephen M. Hewitt,Girish Mallya Udupi,William M. Gallagher,Craig D. Wegner,Brian L. West,Andrea Wang-Gillam,Peter S. Goedegebuure,David C. Linehan,David G. DeNardo +18 more
TL;DR: These findings show how targeting TAMs can effectively overcome therapeutic resistance mediated by TICs and improve chemotherapeutic efficacy, inhibits metastasis, and increases antitumor T-cell responses.
Journal ArticleDOI
CXCR4 regulates growth of both primary and metastatic breast cancer.
Matthew C. P. Smith,Kathryn E. Luker,Joel R. Garbow,Julie L. Prior,Erin Jackson,David Piwnica-Worms,Gary D. Luker +6 more
TL;DR: Data indicate that CXCR4 is required to initiate proliferation and/or promote survival of breast cancer cells in vivo and suggest that CxCR4 inhibitors will improve treatment of patients with primary and metastatic breast cancer.