D
David R. Weaver
Researcher at University of Massachusetts Medical School
Publications - 162
Citations - 30628
David R. Weaver is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 68, co-authored 151 publications receiving 29034 citations. Previous affiliations of David R. Weaver include University of Massachusetts Boston & Yonsei University.
Papers
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Journal ArticleDOI
Coordination of circadian timing in mammals
TL;DR: Circadian rhythms are generated by one of the most ubiquitous and well-studied timing systems and are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
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mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.
Kazuhiko Kume,Mark J. Zylka,Sathyanarayanan Sriram,Lauren P. Shearman,David R. Weaver,Xiaowei Jin,Elizabeth S. Maywood,Michael H. Hastings,Steven M. Reppert +8 more
TL;DR: It is determined that two mouse cryptochrome genes, mCry1 and mCry2, act in the negative limb of the clock feedback loop, and the mPER and mCRY proteins appear to inhibit the transcriptional complex differentially.
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Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
Ralph Scully,Junjie Chen,Annemieke W. Plug,Yonghong Xiao,David R. Weaver,Jean Feunteun,Terry Ashley,David M. Livingston +7 more
TL;DR: Findings suggest a functional interaction between BRCA1 and Rad51 in the meiotic and mitotic cell cycles, which, in turn, suggests a role for BRC a1 in the control of recombination and of genome integrity.
Journal ArticleDOI
Molecular Analysis of Mammalian Circadian Rhythms
TL;DR: Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing.
Journal ArticleDOI
Interacting Molecular Loops in the Mammalian Circadian Clock
Lauren P. Shearman,Sathyanarayanan Sriram,David R. Weaver,Elizabeth S. Maywood,Inẽs Chaves,Binhai Zheng,Kazuhiko Kume,Cheng Chi Lee,Gijsbertus T. J. van der,Horst,Michael H. Hastings,Steven M. Reppert +11 more
TL;DR: Analysis of Clock/Clock mutant mice, homozygous Period2(Brdm1) mutants, and Cryptochrome-deficient mice reveals substantially altered Bmal1 rhythms, consistent with a dominant role of PERIOD2 in the positive regulation of the Bmal 1 loop.