Essentiality Toxicity Carcinogenicity Lead(Pb) Exposure Toxicokinetics Toxicity Neurologic, Neurobehavioral, and Developmental Effects in Children Mechanisms of Effects on the Developing Nervous System Peripheral Neuropathy Hematologic Effects Renal Toxicity Lead and Gout Effects on Cardiovascular System Immunotoxicity Bone Effects Reproductive Effects Birth Outcomes Carcinogenicity Other Effects Dose Response Treatment Organic Lead Compounds Mercury (Hg) Exposure Disposition and Toxicokinetics Metabolic Transformation Cellular Metabolism Toxicology Biological Indicators Treatment Nickel (Ni) Exposure Toxicokinetics Essentiality Toxicity Nickel Carbonyl Poisoning Dermatitis Indicators of Nickel Toxicity

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Toxic effects of metals

Note: This article was originally published with an incorrect version of the Acknowledgments, which appeared on p. 218 of the print version. The correct version of the Acknowledgments appeared on pp. 1–2. The corrected article is available below.

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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide

The assessment of fetal growth.

The interactions of metal ions with quinolone antibacterial agents

Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized

Introduction: The Elemental Composition of the Human Body: Metal Ions, Complexes, and Chemical Speciation: Chelation, Ligands, and Drugs: Delivery of Trace Elements to Humans: Agents Containing Metals: Chelating Agents and Therapy: Dietary and Environmental Aspects: The Future: Subject Index

Trace Elements Medicine and Chelation Therapy

The synthesis and screening for anti-bacterial, -cancer, -fungicidal and -viral activities of some complexes of palladium and nickel

Speciation studies of adriamycin, quelamycin and their metal complexes

Formation constants for the aluminum phosphate system and particle size analyses for solutions containing this material are reported. From a database of (i) the total ligand and metal concentrations in saliva, stomach juice, small intestinal fluid, milk, blood plasma and intravenous fluid, and (ii) physico-chemical constants for all feasible reactions involving low molecular mass complexes, a series of computer models was constructed and used to calculate the distribution of chemical species at equilibrium. The pie-diagrams of speciation indicate that some aluminum complexes exist as net-neutral charged species (which are potentially bioavailable) whereas others are charged and so are highly solvated and/or removed by the renal system. The chemical speciation knowledge produced in this research can be useful in researching aluminum intoxication, prevention and decontamination therapies.

Low Molecular Mass Aluminum Complex Speciation in Biofluids

In recent years there has been a growing awareness of the importance of trace metals in the environment, in their dichotomous role as essential nutritional factors on the one hand, and as toxic agents on the other. The apparent ambivalent nature of metal ions is shown as a continuum in a wide range dose-response curve. The response on the curve, being a function of dosage, covers survival of the organism through a deficiency state to normal health, toxicity, and death. This particular review deals with the toxic effects of this dose-response curve and the use of chelating agents to remove execessive quantities of metal ions which are producing toxic effects. The metals discussed include: (1) Heavy metal ions-lead, mercury, and cadmium; (2) essential trace metals in toxic excessive quantities-chromium, cobalt, copper, iron, manganese, molybdenum, selenium, and zinc; (3) less common toxic metal ions-aluminum, antimony, arsenic, beryllium, nickel, tellurium, thallium, and tin. Radioactive metals are ...

David R. Williams

Papers

Trace Elements Medicine and Chelation Therapy

The synthesis and screening for anti-bacterial, -cancer, -fungicidal and -viral activities of some complexes of palladium and nickel

Speciation studies of adriamycin, quelamycin and their metal complexes

Low Molecular Mass Aluminum Complex Speciation in Biofluids

Chelating Agents in Medicine