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David S. Breslow

Other affiliations: Hercules Inc.
Bio: David S. Breslow is an academic researcher from Wilmington University. The author has contributed to research in topics: Alkyl & Polymerization. The author has an hindex of 21, co-authored 59 publications receiving 2210 citations. Previous affiliations of David S. Breslow include Hercules Inc..
Topics: Alkyl, Polymerization, Sodium, Ethylene, Cobalt



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Journal ArticleDOI
TL;DR: The role of the Michael addition reaction in polymer synthesis with attention to applications in emerging technologies including biomedical, pharmaceutical, optoelectronic, composites, adhesives, and coatings is outlined.

957 citations

Journal ArticleDOI
TL;DR: In this article, a model for pharmacologically active polymers is presented for continuous variation in (a) solubility and toxicity, (b) fixation and removal of active material, and (c) body distribution.
Abstract: Although the concept of using pharmacologically active macromolecular compounds as drugs is still regarded with much skepticism for both theoretical and practical reasons, interest in this field has grown in recent years because of the opportunity to take advantage of the specific properties of polymeric materials. For low molecular weight drugs, changes in structure often lead to a loss of specific activity. On the other hand, the properties of macromolecular drugs depend on the structure of the polymer used and this can be varied over a wide range by the incorporation of comonomer units, by the application of polymer-analogous reactions, or by related structural changes. A new model is presented for pharmacologically active polymers which incorporates the possibility for continuous variation in (a) solubility and toxicity, (b) fixation and removal of active material, and (c) body distribution. Using the new model as a guide, examples of the synthesis and study of the biological activity of various macromolecular drugs are presented in order to emphasize the importance of this cooperative effort between polymer research and therapeutic problems.

939 citations