D
David S. Duch
Researcher at Research Triangle Park
Publications - 60
Citations - 2557
David S. Duch is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Tetrahydrobiopterin & Thymidylate synthase. The author has an hindex of 25, co-authored 60 publications receiving 2503 citations.
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Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.
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Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine
TL;DR: In this paper, the synthesis of 2,4-diamino-7,8-dihydro-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine (BW301U, 7) by a route that has general applicability to the preparation of many 6-(substituted benzyl) 5-methyl pyridines is described.
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Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma
TL;DR: The data show that the antiproliferative effect of IFN-gamma through induction of indoleamine 2,3-dioxygenase, with a consequent L-tryptophan deprivation, is an effective means of regulating cell growth.
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Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo.
TL;DR: Mammalian cells and tissues were found to have two pathways for the biosynthesis of tetrahydrobiopterin (BH4): the conversion of GTP to BH4 by a methotrexate-insensitive de novo pathway and a pterin salvage pathway dependent on dihydrofolate reductase.
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Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species
TL;DR: Levels of GTP cyclohydrolase, neopterin and biopterin were determined in tissues and body fluids of humans, monkey, dog and mouse, while none could be detected in mouse, rat, guinea pig or hamster urine.