David S. Menaldino

TL;DR: The findings establish that the major structural features required for inhibition of protein kinase C and cellular processes dependent on this enzyme are the presence of a free amino group and an aliphatic side chain and that other groups have more subtle effects.

TL;DR: The studies demonstrate that the 1-hydroxyl group is not required for sphingoid bases to be acylated; both erythro- andthreo-isomers are acylation with the highest apparent V max/K m for theerythro -analogs; and AP1 is acylations to PAP1, a new category of ceramide synthase inhibitor as well as a toxic metabolite that may play a role in the diseases caused by fum

TL;DR: A stereoselective synthesis of each of the four enantiomers of sphingosine from either L- or D-serine is reported, and the key steps involve the diastereoselectives addition of 1-lithiopentadecyne to aldehyde 4 and Mitsunobu inversion of propargyl alcohol 5.

TL;DR: Methods for the preparation of libraries of sphingoid bases, including a series of 1-deoxy-analogs, as well as information about their metabolism and biological activities are described.

TL;DR: Studies with diverse types of cells have established that fumonisin B1 not only blocks the biosynthesis of complex sphingolipids; but also, causes sphinganine to accumulate, which may account for the toxicity, and perhaps the carcinogenicity, offumonisins.