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David S. Wald
Researcher at Queen Mary University of London
Publications - 91
Citations - 7300
David S. Wald is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Population & Homocysteine. The author has an hindex of 24, co-authored 87 publications receiving 6571 citations. Previous affiliations of David S. Wald include Southampton General Hospital & St Bartholomew's Hospital.
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Journal ArticleDOI
Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis
TL;DR: Whether the association of serum homocysteine concentration with ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is causal and, if so, to quantify the effect of homocy Steine reduction in preventing them, there is strong evidence that the association between homocy steine and cardiovascular disease is causal.
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Randomized trial of preventive angioplasty in myocardial infarction.
David S. Wald,Joan K. Morris,Nicholas J. Wald,Alexander Chase,Richard Edwards,Liam O. Hughes,Colin Berry,Keith G. Oldroyd +7 more
TL;DR: In patients with STEMI and multivessel coronary artery disease undergoing infarct-artery PCI, preventive PCI in noninfarct coronary arteries with major stenoses significantly reduced the risk of adverse cardiovascular events, as compared with PCI limited to the infarCT artery.
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Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials.
TL;DR: Blood pressure reduction from combining drugs from these 4 classes can be predicted on the basis of additive effects, and doubling the dose of 1 drug had approximately one fifth of the equivalent incremental effect.
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Adherence to Drugs That Prevent Cardiovascular Disease: Meta-analysis on 376,162 Patients
TL;DR: Adherence to preventive treatment is poor and little related to class of drug, suggesting that side effects are not the main cause and general, rather than class-specific, measures are needed.
Journal Article
Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials
Robert Clarke,Chris Frost,Paul Sherliker,Sarah Lewington,Rory Collins,Lars Brattström,Ingeborg A. Brouwer,M. van Dusseldorp,Rpm Steegers-Theunissen,Geraldine Cuskelly,Mark Ward,Helene McNulty,John D. Scott,M. den Heijer,Henk J. Blom,N.M.J. van der Put,CJ Shorah,Malinow,M McMahon,Jonathan A. Tobert,D Kush,E Joosten,R Riezier,Klaus Pietrzik,Jutta Dierkes,A Bronstrup,Paul F. Jacques,Joel B. Mason,Irwin H. Rosenberg,J Thambyrajah,Martin J Landray,Jonathan N. Townend,David C. Wheeler,J. Ubbink,F.V.A. van Oort,Alida Melse-Boonstra,Petra Verhoef,Jayne V. Woodside,J. W. G. Yarnell,Ian S. Young,Alun Evans,David S. Wald,Malcolm Law,Nicholas J. Wald +43 more
TL;DR: The objectives were to ascertain the lowest dose of folic acid associated with the maximum reduction in homocysteine concentrations and to determine the additional relevance of vitamins B-12 and B-6.