D
David Spiegel
Researcher at Stanford University
Publications - 838
Citations - 50967
David Spiegel is an academic researcher from Stanford University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 106, co-authored 733 publications receiving 46276 citations. Previous affiliations of David Spiegel include Tel Aviv University & University of Adelaide.
Papers
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Journal ArticleDOI
A Nanobody Activation Immunotherapeutic that Selectively Destroys HER2‐Positive Breast Cancer Cells
TL;DR: A rationally designed nanobody activation immunotherapeutic is reported that selectively redirects anti‐dinitrophenyl (anti‐DNP) antibodies to the surface of HER2‐positive breast cancer cells, resulting in their targeted destruction by antibody‐dependent cellular cytotoxicity.
Journal ArticleDOI
Chemically Synthesized Molecules with the Targeting and Effector Functions of Antibodies
Patrick J. McEnaney,Kelly J. Fitzgerald,Andrew Zhang,Eugene F. Douglass,Weifang Shan,Aaron Balog,Mariya D. Kolesnikova,David Spiegel +7 more
TL;DR: A novel class of molecules of intermediate size, which possess both the targeting and effector functions of antibodies, which bind simultaneously to prostate-specific membrane antigen and Fc gamma receptor I, thus eliciting highly selective cancer cell phagocytosis are reported.
Journal ArticleDOI
Cytotoxic T lymphocyte count and survival time in women with metastatic breast cancer.
TL;DR: There is a robust relationship between CTL count and survival that is independent of the effects of medical treatments, TWC count, and Karnofsky performance status, and a reduced C TL count may be a mediator or marker of more rapid disease progression in metastatic breast cancer.
Book
Efficacy and cost-effectiveness of psychotherapy
TL;DR: This book discusses the cognitive-behavioral theory and treatment of posttraumatic stress disorder and other trauma-related disorders, and the contemporary practice of inpatient psychotherapy.