D
David T. Denhardt
Researcher at Rutgers University
Publications - 270
Citations - 27302
David T. Denhardt is an academic researcher from Rutgers University. The author has contributed to research in topics: Osteopontin & DNA. The author has an hindex of 77, co-authored 270 publications receiving 26428 citations. Previous affiliations of David T. Denhardt include Swarthmore College & University of Washington.
Papers
More filters
Journal ArticleDOI
Eta-1 (Osteopontin): An Early Component of Type-1 (Cell-Mediated) Immunity
Samy Ashkar,Georg F. Weber,Vassiliki Panoutsakopoulou,Marie E. Sanchirico,Marianne Jansson,Samer Zawaideh,Susan R. Rittling,David T. Denhardt,Melvin J. Glimcher,Harvey Cantor +9 more
TL;DR: Findings identify Eta-1 as a key cytokine that sets the stage for efficient type-1 immune responses through differential regulation of macrophage IL-12 and IL-10 cytokine expression.
Journal ArticleDOI
Osteopontin: a protein with diverse functions.
David T. Denhardt,Xiaojia Guo +1 more
TL;DR: In this review most of the various known, suspected, or postulated functions of osteopontin, a secreted highly acidic phosphoprotein, are discussed in terms of what the authors currently know about the protein.
Journal ArticleDOI
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
TL;DR: It is suggested that OPN delivers an antiapoptotic “ECM-like” signal via multiple ligand-receptor interactions to cells, both adherent and nonadherent.
Journal ArticleDOI
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease.
Dorothee Chabas,Sergio E. Baranzini,Dennis J. Mitchell,Claude C.A. Bernard,Susan R. Rittling,David T. Denhardt,Raymond A. Sobel,Christopher Lock,Marcela Karpuj,Marcela Karpuj,Rosetta Pedotti,Renu A. Heller,Jorge R. Oksenberg,Lawrence Steinman +13 more
TL;DR: Osteopontin appears to regulate T helper cell–1 (TH1)–mediated demyelinating disease, and it may offer a potential target in blocking development of progressive MS.