David W. Crabb

TL;DR: The genotypes of the ADH2, ADH3, and ALDH2 loci of alcoholic and nonalcoholic Chinese men living in Taiwan are determined using leukocyte DNA amplified by the PCR and allele-specific oligonucleotides, suggesting that genetic variation in both ADH and AL DH, by modulating the rate of metabolism of ethanol and acetaldehyde, influences drinking behavior and the risk of developing alcoholism.

TL;DR: The polymerase chain reaction is used to determine the genotypes of 24 livers from Japanese individuals and it is concluded that the allele (ALDH2(2)) encoding the abnormal subunit is dominant.

TL;DR: This article used the polymerase chain reaction to determine the genotype of 24 livers from Japanese individuals and found that the allele (ALDH22) encoding the abnormal subunit is dominant.

TL;DR: It is suggested that metabolism of ethanol increased hepatic lipogenesis by activating SREBP-1 and that this effect of ethanol may contribute to the development of alcoholic fatty liver.

TL;DR: The strongest correlations found to date have been those between the ALDH2*2 allele and cancers of the oro-pharynx and oesophagus, and it will be important to replicate other interesting associations between these variants and other cancers and heart disease, and to determine the biochemical mechanisms underlying the associations.