David White

Bio: David White is an academic researcher from University of Southampton. The author has contributed to research in topics: Centrifuge & Pile. The author has an hindex of 55, co-authored 520 publications receiving 11856 citations. Previous affiliations of David White include Robarts Research Institute & University of Hong Kong.

Soil deformation measurement using particle image velocimetry (PIV) and photogrammetry

Abstract: A deformation measurement system based on particle image velocimetry (PIV) and close-range photogrammetry has been developed for use in geotechnical testing. In this paper, the theory underlying this system is described, and the performance is validated. Digital photography is used to capture images of planar soil deformation. Using PIV, the movement of a fine mesh of soil patches is measured to a high precision. Since PIV operates on the image texture, intrusive target markers need not be installed in the observed soil. The resulting displacement vectors are converted from image space to object space using a photogrammetric transformation. A series of validation experiments are reported. These demonstrate that the precision, accuracy and resolution of the system are an order of magnitude higher than previous image-based deformation methods, and are comparable to local instrumentation used in element testing. This performance is achieved concurrent with an order of magnitude increase in the number of meas...

Improved image-based deformation measurement for geotechnical applications

Abstract: This paper describes and benchmarks a new implementation of image-based deformation measurement for geotechnical applications. The updated approach combines a range of advances in image analysis al...

Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors.

Abstract: Background. In order to circumvent the complement-mediated hyperacute rejection of discordant xenografts, a colony of pigs transgenic for the human regulator of complement activity, human decay-accelerating factor (hDAF), has been produced. Methods. Seven kidneys from hDAF transgenic pigs and six kidneys from nontransgenic control pigs were transplanted into cynomolgus monkeys; both native kidneys were removed during the same operation. The recipient animals were immunosuppressed with cyclosporine, steroids, and cyclophosphamide. Results. In the transgenic group, the median survival time was 13 days (range, 6-35 days); the median survival time in the control group was 6.5 days (range, 0.3-30 days). There were no cases of hyperacute rejection in the transgenic group, and the two longest-surviving kidneys in this group showed no evidence of rejection on histological examination. In contrast, all control kidneys underwent antibody-mediated rejection, one demonstrating hyperacute rejection and the others acute vascular rejection. Conclusion. This study demonstrates that (i) a kidney from an hDAF transgenic pig can support the life of a primate for up to 35 days (and also shows the basic physiological compatibility between the pig and non-human primate); (ii) nontransgenic kidneys are not routinely hyperacutely rejected; and (iii) the presence of hDAF on the kidney confers some protection against acute vascular rejection. Improved immunosuppression and immunological monitoring may enable extended survival.

Displacement and strain paths during plane-strain model pile installation in sand

Abstract: The underlying mechanisms governing the behaviour of displacement piles in sand are not well understood, leading to unreliability in design methods. A series of plane-strain calibration chamber tes...

Inhibitory Feedback Loop Between Tolerogenic Dendritic Cells and Regulatory T Cells in Transplant Tolerance

Abstract: An active role of T regulatory cells (Treg) and tolerogenic dendritic cells (Tol-DC) is believed important for the induction and maintenance of transplantation tolerance. However, interactions between these cells remain unclear. We induced donor-specific tolerance in a fully MHC-mismatched murine model of cardiac transplantation by simultaneously targeting T cell and DC function using anti-CD45RB mAb and LF 15-0195, a novel analog of the antirejection drug 15-deoxyspergualin, respectively. Increases in splenic Treg and Tol-DC were observed in tolerant recipients as assessed by an increase in CD4 + CD25 + T cells and DC with immature phenotype. Both these cell types exerted suppressive effects in MLR. Tol-DC purified from tolerant recipients incubated with naive T cells induced the generation/expansion of CD4 + CD25 + Treg. Furthermore, incubation of Treg isolated from tolerant recipients with DC progenitors resulted in the generation of DC with Tol-DC phenotype. Treg and Tol-DC generated in vitro were functional based on their suppressive activity in vitro. These results are consistent with the notion that tolerance induction is associated with a self-maintaining regulatory loop in which Tol-DC induce the generation of Treg from naive T cells and Treg programs the generation of Tol-DC from DC progenitors.

American Society for Testing and Materials

Abstract: The American Society for Testing and Materials (ASTM) is an independent organization devoted to the development of standards.

The Environmental Protection Agency

Abstract: The Environmental Protection Agency (EPA) provides access to information on a variety of topics related to the environment and strives to inform citizens of health risks. The EPA also has an extensive library network that consists of 26 libraries throughout the United States, which provide access to a plethora of information to EPA employees, scientists, and researchers. The EPA implemented a reorganization project to digitize their materials so they would be more accessible to a wider range of users, but this plan was drastically accelerated when the EPA was threatened with a budget cut. It chose to close and reduce the hours and services of some of their libraries. As a result, the agency was accused of denying users the “right to know” by making information unavailable, not providing an adequate strategic plan, and discarding vital materials. This case study explores the background of the digitization project, the practices implemented, and the critiques of the project.

Two-dimensional digital image correlation for in-plane displacement and strain measurement: a review

Abstract: As a practical and effective tool for quantitative in-plane deformation measurement of a planar object surface, two-dimensional digital image correlation (2D DIC) is now widely accepted and commonly used in the field of experimental mechanics. It directly provides full-field displacements to sub-pixel accuracy and full-field strains by comparing the digital images of a test object surface acquired before and after deformation. In this review, methodologies of the 2D DIC technique for displacement field measurement and strain field estimation are systematically reviewed and discussed. Detailed analyses of the measurement accuracy considering the influences of both experimental conditions and algorithm details are provided. Measures for achieving high accuracy deformation measurement using the 2D DIC technique are also recommended. Since microscale and nanoscale deformation measurement can easily be realized by combining the 2D DIC technique with high-spatial-resolution microscopes, the 2D DIC technique should find more applications in broad areas.

Properties Of Concrete

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