Davide Lonardoni

TL;DR: The ability of 3D geometry to improve functional organization and synchronization in small neuronal assemblies is reported, and a mathematical modelling of network dynamics that supports such a result is proposed.

TL;DR: The results suggest that the presence of functional neuronal communities with recurrent local connections allows a neuronal system to generate spontaneous coordinated spiking activity events, as suggested by the rules used for implementing the computational model.

TL;DR: A simple yet powerful in vitro AD model based on a rat hippocampal cell culture system that exploits large-scale neuronal recordings from 4096-electrodes on CMOS-chips for electrophysiological quantifications is demonstrated and the role of extrasynaptic-NMDA receptors activation that may contribute to Aβ-neurotoxicity is confirmed.

TL;DR: Analysis of the phenotype of primary hippocampal neurons obtained from mouse embryos in which the PRRT2 gene was constitutively inactivated indicates the existence of network instability/hyperexcitability as the possible basis of the paroxysmal phenotypes associated withPRRT2 mutations.

TL;DR: In this article, the authors used FAPESP Research, Disseminations and Innovation Center for Neuromathematics (CNPq) for postdoctoral research.