D
Davina J. Honess
Researcher at University of Cambridge
Publications - 31
Citations - 3886
Davina J. Honess is an academic researcher from University of Cambridge. The author has contributed to research in topics: Cancer & Thymidine kinase 1. The author has an hindex of 17, co-authored 31 publications receiving 3570 citations. Previous affiliations of Davina J. Honess include Cancer Research UK & Mount Vernon Hospital.
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Journal ArticleDOI
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
Journal ArticleDOI
Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1
Kaye J. Williams,Brian A. Telfer,Dia Xenaki,Dia Xenaki,Mary R. Sheridan,Isabelle Desbaillets,Hans J.W. Peters,Davina J. Honess,Adrian L. Harris,Gabi U. Dachs,Albert J. van der Kogel,Ian J. Stratford +11 more
TL;DR: The differences in radioresponse do not correlate with tumour oxygenation, suggesting that the hypoxic cells within the HIF-1 deficient tumours do not contribute to the outcome of radiotherapy.
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The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses
TL;DR: Analysis of the antivascular actions of disodium combretastatin A-4 3-O-phosphate in the rat P22 carcinosarcoma provided an insight into the mechanisms underlying tissue blood flow changes occurring after clinically relevant doses of CA-4-P.
Journal ArticleDOI
Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
Shen-Han Lee,Shen-Han Lee,Dominick J.O. McIntyre,Davina J. Honess,Alzbeta Hulikova,Jesús Pacheco-Torres,Sebastián Cerdán,Pawel Swietach,Adrian L. Harris,John R. Griffiths +9 more
TL;DR: It is proposed that CAIX acts as an extracellular pH-stat, maintaining an acidic tumour extrace cellular pH that is tolerated by cancer cells and favours invasion and metastasis.
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Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy
TL;DR: Doses of nicotinamide that can be tolerated clinically should produce adequate enhancements of radiation damage in human tumours, although the elimination half-lives were not dose-dependent.