Dayong Wang

Bio: Dayong Wang is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Image retrieval & Content-based image retrieval. The author has an hindex of 19, co-authored 28 publications receiving 3845 citations. Previous affiliations of Dayong Wang include Michigan State University & Beth Israel Deaconess Medical Center.

Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer.

Abstract: Importance Application of deep learning algorithms to whole-slide pathology images can potentially improve diagnostic accuracy and efficiency. Objective Assess the performance of automated deep learning algorithms at detecting metastases in hematoxylin and eosin–stained tissue sections of lymph nodes of women with breast cancer and compare it with pathologists’ diagnoses in a diagnostic setting. Design, Setting, and Participants Researcher challenge competition (CAMELYON16) to develop automated solutions for detecting lymph node metastases (November 2015-November 2016). A training data set of whole-slide images from 2 centers in the Netherlands with (n = 110) and without (n = 160) nodal metastases verified by immunohistochemical staining were provided to challenge participants to build algorithms. Algorithm performance was evaluated in an independent test set of 129 whole-slide images (49 with and 80 without metastases). The same test set of corresponding glass slides was also evaluated by a panel of 11 pathologists with time constraint (WTC) from the Netherlands to ascertain likelihood of nodal metastases for each slide in a flexible 2-hour session, simulating routine pathology workflow, and by 1 pathologist without time constraint (WOTC). Exposures Deep learning algorithms submitted as part of a challenge competition or pathologist interpretation. Main Outcomes and Measures The presence of specific metastatic foci and the absence vs presence of lymph node metastasis in a slide or image using receiver operating characteristic curve analysis. The 11 pathologists participating in the simulation exercise rated their diagnostic confidence as definitely normal, probably normal, equivocal, probably tumor, or definitely tumor. Results The area under the receiver operating characteristic curve (AUC) for the algorithms ranged from 0.556 to 0.994. The top-performing algorithm achieved a lesion-level, true-positive fraction comparable with that of the pathologist WOTC (72.4% [95% CI, 64.3%-80.4%]) at a mean of 0.0125 false-positives per normal whole-slide image. For the whole-slide image classification task, the best algorithm (AUC, 0.994 [95% CI, 0.983-0.999]) performed significantly better than the pathologists WTC in a diagnostic simulation (mean AUC, 0.810 [range, 0.738-0.884];P Conclusions and Relevance In the setting of a challenge competition, some deep learning algorithms achieved better diagnostic performance than a panel of 11 pathologists participating in a simulation exercise designed to mimic routine pathology workflow; algorithm performance was comparable with an expert pathologist interpreting whole-slide images without time constraints. Whether this approach has clinical utility will require evaluation in a clinical setting.

Deep Learning for Content-Based Image Retrieval: A Comprehensive Study

Abstract: Learning effective feature representations and similarity measures are crucial to the retrieval performance of a content-based image retrieval (CBIR) system. Despite extensive research efforts for decades, it remains one of the most challenging open problems that considerably hinders the successes of real-world CBIR systems. The key challenge has been attributed to the well-known ``semantic gap'' issue that exists between low-level image pixels captured by machines and high-level semantic concepts perceived by human. Among various techniques, machine learning has been actively investigated as a possible direction to bridge the semantic gap in the long term. Inspired by recent successes of deep learning techniques for computer vision and other applications, in this paper, we attempt to address an open problem: if deep learning is a hope for bridging the semantic gap in CBIR and how much improvements in CBIR tasks can be achieved by exploring the state-of-the-art deep learning techniques for learning feature representations and similarity measures. Specifically, we investigate a framework of deep learning with application to CBIR tasks with an extensive set of empirical studies by examining a state-of-the-art deep learning method (Convolutional Neural Networks) for CBIR tasks under varied settings. From our empirical studies, we find some encouraging results and summarize some important insights for future research.

Deep Learning for Identifying Metastatic Breast Cancer

Abstract: The International Symposium on Biomedical Imaging (ISBI) held a grand challenge to evaluate computational systems for the automated detection of metastatic breast cancer in whole slide images of sentinel lymph node biopsies. Our team won both competitions in the grand challenge, obtaining an area under the receiver operating curve (AUC) of 0.925 for the task of whole slide image classification and a score of 0.7051 for the tumor localization task. A pathologist independently reviewed the same images, obtaining a whole slide image classification AUC of 0.966 and a tumor localization score of 0.733. Combining our deep learning system's predictions with the human pathologist's diagnoses increased the pathologist's AUC to 0.995, representing an approximately 85 percent reduction in human error rate. These results demonstrate the power of using deep learning to produce significant improvements in the accuracy of pathological diagnoses.

Online multimodal deep similarity learning with application to image retrieval

Abstract: Recent years have witnessed extensive studies on distance metric learning (DML) for improving similarity search in multimedia information retrieval tasks. Despite their successes, most existing DML methods suffer from two critical limitations: (i) they typically attempt to learn a linear distance function on the input feature space, in which the assumption of linearity limits their capacity of measuring the similarity on complex patterns in real-world applications; (ii) they are often designed for learning distance metrics on uni-modal data, which may not effectively handle the similarity measures for multimedia objects with multimodal representations. To address these limitations, in this paper, we propose a novel framework of online multimodal deep similarity learning (OMDSL), which aims to optimally integrate multiple deep neural networks pretrained with stacked denoising autoencoder. In particular, the proposed framework explores a unified two-stage online learning scheme that consists of (i) learning a flexible nonlinear transformation function for each individual modality, and (ii) learning to find the optimal combination of multiple diverse modalities simultaneously in a coherent process. We conduct an extensive set of experiments to evaluate the performance of the proposed algorithms for multimodal image retrieval tasks, in which the encouraging results validate the effectiveness of the proposed technique.

“Bioinformatics” 특집을 내면서

Abstract: BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

Object Detection With Deep Learning: A Review

Abstract: Due to object detection’s close relationship with video analysis and image understanding, it has attracted much research attention in recent years. Traditional object detection methods are built on handcrafted features and shallow trainable architectures. Their performance easily stagnates by constructing complex ensembles that combine multiple low-level image features with high-level context from object detectors and scene classifiers. With the rapid development in deep learning, more powerful tools, which are able to learn semantic, high-level, deeper features, are introduced to address the problems existing in traditional architectures. These models behave differently in network architecture, training strategy, and optimization function. In this paper, we provide a review of deep learning-based object detection frameworks. Our review begins with a brief introduction on the history of deep learning and its representative tool, namely, the convolutional neural network. Then, we focus on typical generic object detection architectures along with some modifications and useful tricks to improve detection performance further. As distinct specific detection tasks exhibit different characteristics, we also briefly survey several specific tasks, including salient object detection, face detection, and pedestrian detection. Experimental analyses are also provided to compare various methods and draw some meaningful conclusions. Finally, several promising directions and tasks are provided to serve as guidelines for future work in both object detection and relevant neural network-based learning systems.

High-performance medicine: the convergence of human and artificial intelligence

Abstract: The use of artificial intelligence, and the deep-learning subtype in particular, has been enabled by the use of labeled big data, along with markedly enhanced computing power and cloud storage, across all sectors. In medicine, this is beginning to have an impact at three levels: for clinicians, predominantly via rapid, accurate image interpretation; for health systems, by improving workflow and the potential for reducing medical errors; and for patients, by enabling them to process their own data to promote health. The current limitations, including bias, privacy and security, and lack of transparency, along with the future directions of these applications will be discussed in this article. Over time, marked improvements in accuracy, productivity, and workflow will likely be actualized, but whether that will be used to improve the patient-doctor relationship or facilitate its erosion remains to be seen.

Efficient Processing of Deep Neural Networks: A Tutorial and Survey

Abstract: Deep neural networks (DNNs) are currently widely used for many artificial intelligence (AI) applications including computer vision, speech recognition, and robotics. While DNNs deliver state-of-the-art accuracy on many AI tasks, it comes at the cost of high computational complexity. Accordingly, techniques that enable efficient processing of DNNs to improve energy efficiency and throughput without sacrificing application accuracy or increasing hardware cost are critical to the wide deployment of DNNs in AI systems. This article aims to provide a comprehensive tutorial and survey about the recent advances toward the goal of enabling efficient processing of DNNs. Specifically, it will provide an overview of DNNs, discuss various hardware platforms and architectures that support DNNs, and highlight key trends in reducing the computation cost of DNNs either solely via hardware design changes or via joint hardware design and DNN algorithm changes. It will also summarize various development resources that enable researchers and practitioners to quickly get started in this field, and highlight important benchmarking metrics and design considerations that should be used for evaluating the rapidly growing number of DNN hardware designs, optionally including algorithmic codesigns, being proposed in academia and industry. The reader will take away the following concepts from this article: understand the key design considerations for DNNs; be able to evaluate different DNN hardware implementations with benchmarks and comparison metrics; understand the tradeoffs between various hardware architectures and platforms; be able to evaluate the utility of various DNN design techniques for efficient processing; and understand recent implementation trends and opportunities.