D
De-Hyung Lee
Researcher at University of Erlangen-Nuremberg
Publications - 42
Citations - 3066
De-Hyung Lee is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Multiple sclerosis. The author has an hindex of 21, co-authored 39 publications receiving 2562 citations. Previous affiliations of De-Hyung Lee include University of Göttingen & Ruhr University Bochum.
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Journal ArticleDOI
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
Ralf A. Linker,De-Hyung Lee,Sarah Ryan,Anne M van Dam,Rebecca Conrad,Pradeep Bista,Weike Zeng,Xiaoping Hronowsky,Alex Buko,Sowmya Chollate,Gisa Ellrichmann,Wolfgang Brück,Kate Dawson,Susan Goelz,Stefan Wiese,Robert H. Scannevin,Matvey E. Lukashev,Ralf Gold +17 more
TL;DR: The ability of dimethylfumarate to activate nuclear factor (erythroid-derived 2)-related factor 2 may offer a novel cytoprotective modality that further augments the natural antioxidant responses in multiple sclerosis tissue and is not yet targeted by other multiple sclerosis therapies.
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Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine
Aiden Haghikia,Stefanie Jörg,Alexander Duscha,Johannes Berg,Arndt Manzel,Anne Waschbisch,Anna Hammer,De-Hyung Lee,Caroline May,Nicola Wilck,András Balogh,Annika I. Ostermann,Nils Helge Schebb,Denis A. Akkad,Diana A. Grohme,Markus Kleinewietfeld,Stefan Kempa,Jan Thöne,Seray Demir,Dominik N. Müller,Ralf Gold,Ralf A. Linker +21 more
TL;DR: Dietary long-chain fatty acids enhanced differentiation and proliferation of T helper 1 and/or Th17 cells and impaired their intestinal sequestration via p38-MAPK pathway and dietary short-chain FAs expanded gut T regulatory (Treg) cells by suppression of the JNK1 and p38 pathway.
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Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system
Johannes Stegbauer,De-Hyung Lee,Silvia Seubert,Gisa Ellrichmann,Arndt Manzel,Heda Kvakan,Dominik N. Müller,Stefanie Gaupp,Lars Christian Rump,Ralf Gold,Ralf A. Linker +10 more
TL;DR: A pivotal role of the RAS is suggested in autoimmune inflammation of the central nervous system and RAS blockade is identified as a potential new target for multiple sclerosis therapy.
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Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis
Ralf A. Linker,De-Hyung Lee,Seray Demir,Seray Demir,Stefan Wiese,Niels Kruse,Ines Siglienti,Ellen Gerhardt,Harald Neumann,Michael Sendtner,Fred Lühder,Ralf Gold +11 more
TL;DR: The data imply a functional role of brain-derived neurotrophic factor in autoimmune demyelination by mediating axonal protection in mice deficient for central nervous system-derived brain- derived neurotrophic factors.
Journal ArticleDOI
Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease
Gisa Ellrichmann,Elisabeth Petrasch-Parwez,De-Hyung Lee,Christiane Reick,Larissa Arning,Carsten Saft,Ralf Gold,Ralf A. Linker +7 more
TL;DR: Investigating the therapeutic efficacy of DMF in R6/2 and YAC128 HD transgenic mice, which mimic many aspects of HD and are characterized by an enhanced generation of free radicals in neurons, concluded that DMF may exert beneficial effects in mouse models of HD.