D
Dean P. Jones
Researcher at Emory University
Publications - 750
Citations - 53727
Dean P. Jones is an academic researcher from Emory University. The author has contributed to research in topics: Glutathione & Oxidative stress. The author has an hindex of 104, co-authored 668 publications receiving 46459 citations. Previous affiliations of Dean P. Jones include Hospital for Sick Children & University of Alabama at Birmingham.
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Journal ArticleDOI
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Jie Yang,Xuesong Liu,Xuesong Liu,Kapil N. Bhalla,Caryn Naekyung Kim,Ana Maria Ibrado,Jiyang Cai,Tsung I. Peng,Dean P. Jones,Xiaodong Wang,Xiaodong Wang +10 more
TL;DR: One possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria, which is normally located in the mitochondrial intermembrane space.
Journal ArticleDOI
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.
Helmut Sies,Dean P. Jones +1 more
TL;DR: This work focuses on ROS at physiological levels and their central role in redox signalling via different post-translational modifications, denoted as ‘oxidative eustress’.
Journal ArticleDOI
Redefining oxidative stress.
TL;DR: From a mechanistic standpoint, oxidative stress may be better defined as a disruption of redox signaling and control and adoption of such a definition could redirect research to identify key perturbations of red Oxidative stress-related disease processes and lead to new treatments for oxidative stressed disease processes.
Journal ArticleDOI
Radical-free biology of oxidative stress
TL;DR: Data is summarized supporting a complementary hypothesis for oxidative stress in disease that can occur without free radicals, which is that oxidative stress occurs as a consequence of disruption of thiol redox circuits, which normally function in cell signaling and physiological regulation.
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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
Jason E. Kokoszka,Jason E. Kokoszka,Katrina G. Waymire,Katrina G. Waymire,Shawn Levy,Shawn Levy,James E. Sligh,James E. Sligh,Jiyang Cai,Dean P. Jones,Grant R. MacGregor,Grant R. MacGregor,Douglas C. Wallace,Douglas C. Wallace +13 more
TL;DR: It is shown that mitochondria lacking ANT could still be induced to undergo permeability transition, resulting in release of cytochrome c.